| Presentation | 2002/3/11 Synaptic plasticity via correlated pre- and postsynaptic activity Tatsuo KITAJIMA, Makoto Nishiyama, Ken-ichi HARA, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | It has been demonstrated that correlated activity at 5Hz can induce either LTP or LTD, depending on the precise timing of pre- and postsynaptic activity, and a time window for LTP that exists on the activated pathway is flanked by two time windows for LTD. In this paper our previous model of activity-dependent synaptic modification is applied to a model neuron with two spines on the dendrite, which is used in computer simulations to examine the time window during which the pairing of EPSPs and action potentials can produce such synaptic modifications. Each spine contains an endplasmic reticulum. Computer simulations show that Ca^2+ release from an internal store, activation of Ca^2+ dependent potassium channels and GAMAergic inputs contribute not only to the appearance of two different LTD time windows by correlated pre- and postsynaptic activity, but also regulate the polarity of synaptic modifications according to pattern of postsynaptic Ca^2+ concentration via the interval between pre- and postsynaptic activity. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Activity-dependent synaptic modification / Integrated synaptic learning rule / LTP/LTD time window / Backpropagated asction potential |
| Paper # | NC2001-161 |
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| Committee | NC |
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| Conference Date | 2002/3/11(1days) |
| Place (in Japanese) | (See Japanese page) |
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| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | Neurocomputing (NC) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Synaptic plasticity via correlated pre- and postsynaptic activity |
| Sub Title (in English) | |
| Keyword(1) | Activity-dependent synaptic modification |
| Keyword(2) | Integrated synaptic learning rule |
| Keyword(3) | LTP/LTD time window |
| Keyword(4) | Backpropagated asction potential |
| 1st Author's Name | Tatsuo KITAJIMA |
| 1st Author's Affiliation | Faculty of Engineering Yamagata University() |
| 2nd Author's Name | Makoto Nishiyama |
| 2nd Author's Affiliation | School of Medicine New York University |
| 3rd Author's Name | Ken-ichi HARA |
| 3rd Author's Affiliation | Faculty of Science and Engineering Ishinomaki Sensyu University |
| Date | 2002/3/11 |
| Paper # | NC2001-161 |
| Volume (vol) | vol.101 |
| Number (no) | 735 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |