| Presentation | 2002/3/13 Prion and Brain Damage Kiyotoshi Kaneko, |
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| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Prion protein exists in two different isoforms, a normal cellular isoform (PrP^C) and an abnormal infectious isoform (PrP^Sc), the latter is a causative agent of prion disease such as bovine spongiform encephalopathy (BSE) and Creutzfeldt-Jakob (CJD) disease. Amino acid sequences of PrP^C and PrP^Sc are identical, but their conformations are rather different; PrP^C rich in non β-sheet vs. PrP^Sc rich in β-sheet isoform. Our prion research focuses on further understanding such an unprecedented mechanism by identifying auxiliary factor(s) other than PrP^C and PrP^Sc. Our current targets are, (1) yet unidentified protease cleaving PrP^C during its normal metabolic pathway, and (2) unknown host-specific factor(s) involved in PrP^Sc formation. These studies also help us to develop "therapeutics and prevention methods" in prion disease. Two trials including genetic manipulation with dominant negative mutant PrP^C gene working against the hypothetical host factor, or antibody therapy with anti-PrP antibodies which blocks PrP^C-PrP^Sc binding are currently underway. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Prion / Creutzfeldt-Jakob disease (CJD) / Bovine spongiform encephalopathy (BSE) |
| Paper # | SSS2001-38 |
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| Conference Information | |
| Committee | SSS |
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| Conference Date | 2002/3/13(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | Safety (SSS) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Prion and Brain Damage |
| Sub Title (in English) | |
| Keyword(1) | Prion |
| Keyword(2) | Creutzfeldt-Jakob disease (CJD) |
| Keyword(3) | Bovine spongiform encephalopathy (BSE) |
| 1st Author's Name | Kiyotoshi Kaneko |
| 1st Author's Affiliation | Department of Cortical Function Disorders, National Institute of Neuroscience, National Center of Neurology and Psychiatry() |
| Date | 2002/3/13 |
| Paper # | SSS2001-38 |
| Volume (vol) | vol.101 |
| Number (no) | 739 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |