Presentation 2005/3/22
A compartmental model analysis on the spatio-temporal profile of current responses in pyramidal neuron induced by extracellular DC field
Takahito OWA, Masashi INOUE, Yoshihisa KUDO, Hiroyoshi MIYAKAWA,
PDF Download Page PDF download Page Link
Abstract(in Japanese) (See Japanese page)
Abstract(in English) In pyramidal cell, it has been shown experimentally that external cellular DC field applied parallel to the somato-dendritic axis induce change in membrane potential. Near the cell body, the change is monotonic with slow time course, and the change is biphasic with fast and slow time course. A compartmental cable model with low membrane resistivity on one end shows similar profile of membrane potential change in response to DC field. Here we analyzed various currents induced by applied DC field using a comparmental simulator NEURON, and found that a large resistive current induced early at the leaky end of the cable give rise to the slow component of change in membrane potential.
Keyword(in Japanese) (See Japanese page)
Keyword(in English) pyramidal neuron / extracellular DC field / leaky dendrite / compartmental model
Paper # NC2004-171
Date of Issue

Conference Information
Committee NC
Conference Date 2005/3/22(1days)
Place (in Japanese) (See Japanese page)
Place (in English)
Topics (in Japanese) (See Japanese page)
Topics (in English)
Chair
Vice Chair
Secretary
Assistant

Paper Information
Registration To Neurocomputing (NC)
Language JPN
Title (in Japanese) (See Japanese page)
Sub Title (in Japanese) (See Japanese page)
Title (in English) A compartmental model analysis on the spatio-temporal profile of current responses in pyramidal neuron induced by extracellular DC field
Sub Title (in English)
Keyword(1) pyramidal neuron
Keyword(2) extracellular DC field
Keyword(3) leaky dendrite
Keyword(4) compartmental model
1st Author's Name Takahito OWA
1st Author's Affiliation Laboratory of Cellular Neurobiology, School of Life Science, Tokyo university of Pharmacy and Life Science()
2nd Author's Name Masashi INOUE
2nd Author's Affiliation Laboratory of Cellular Neurobiology, School of Life Science, Tokyo university of Pharmacy and Life Science
3rd Author's Name Yoshihisa KUDO
3rd Author's Affiliation Laboratory of Cellular Neurobiology, School of Life Science, Tokyo university of Pharmacy and Life Science
4th Author's Name Hiroyoshi MIYAKAWA
4th Author's Affiliation Laboratory of Cellular Neurobiology, School of Life Science, Tokyo university of Pharmacy and Life Science
Date 2005/3/22
Paper # NC2004-171
Volume (vol) vol.104
Number (no) 759
Page pp.pp.-
#Pages 5
Date of Issue