| Presentation | 2005/3/22 A compartmental model analysis on the spatio-temporal profile of current responses in pyramidal neuron induced by extracellular DC field Takahito OWA, Masashi INOUE, Yoshihisa KUDO, Hiroyoshi MIYAKAWA, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | In pyramidal cell, it has been shown experimentally that external cellular DC field applied parallel to the somato-dendritic axis induce change in membrane potential. Near the cell body, the change is monotonic with slow time course, and the change is biphasic with fast and slow time course. A compartmental cable model with low membrane resistivity on one end shows similar profile of membrane potential change in response to DC field. Here we analyzed various currents induced by applied DC field using a comparmental simulator NEURON, and found that a large resistive current induced early at the leaky end of the cable give rise to the slow component of change in membrane potential. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | pyramidal neuron / extracellular DC field / leaky dendrite / compartmental model |
| Paper # | NC2004-171 |
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| Committee | NC |
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| Conference Date | 2005/3/22(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Registration To | Neurocomputing (NC) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | A compartmental model analysis on the spatio-temporal profile of current responses in pyramidal neuron induced by extracellular DC field |
| Sub Title (in English) | |
| Keyword(1) | pyramidal neuron |
| Keyword(2) | extracellular DC field |
| Keyword(3) | leaky dendrite |
| Keyword(4) | compartmental model |
| 1st Author's Name | Takahito OWA |
| 1st Author's Affiliation | Laboratory of Cellular Neurobiology, School of Life Science, Tokyo university of Pharmacy and Life Science() |
| 2nd Author's Name | Masashi INOUE |
| 2nd Author's Affiliation | Laboratory of Cellular Neurobiology, School of Life Science, Tokyo university of Pharmacy and Life Science |
| 3rd Author's Name | Yoshihisa KUDO |
| 3rd Author's Affiliation | Laboratory of Cellular Neurobiology, School of Life Science, Tokyo university of Pharmacy and Life Science |
| 4th Author's Name | Hiroyoshi MIYAKAWA |
| 4th Author's Affiliation | Laboratory of Cellular Neurobiology, School of Life Science, Tokyo university of Pharmacy and Life Science |
| Date | 2005/3/22 |
| Paper # | NC2004-171 |
| Volume (vol) | vol.104 |
| Number (no) | 759 |
| Page | pp.pp.- |
| #Pages | 5 |
| Date of Issue | |