| Presentation | 2005/3/22 Role of the intracelluar Ca^<2+> store in intracellular Ca^<2+> oscillations Tatsuo Kitajima, Yuki Sawai, Makoto Nishiyama, |
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| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Intracellular Ca^<2+> and its oscillation play an important role in many cell functions. A number of cells respond to a hormonal stimulus with a periodic oscillation in intracellular Ca^<2+>. Properties of oscillations depend on Ca^<2+>-dependent activation of inositol 1, 4, 5-triphosphate receptors (IP3R) on the endoplasmic reticulum membrane. Baxed on a computer stimulation based on one simple neuron model with endoplasmic reticulum, in which the depletion nad refill dynamics of Ca^<2+> is incorporated, we show intracellular Ca^<2+> oscillations caused by varying the time course of IP3 concentration A contribution of Ca^<2+> dependent IP3 production process and the dynamics of Ca^<2+> in the ER to an Ca^<2+> oscillation are also considered. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | IP3 receptor / phospholipase C / Ca oscillation / Endoplasmic reticulum |
| Paper # | NC2004-170 |
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| Committee | NC |
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| Conference Date | 2005/3/22(1days) |
| Place (in Japanese) | (See Japanese page) |
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| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | Neurocomputing (NC) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Role of the intracelluar Ca^<2+> store in intracellular Ca^<2+> oscillations |
| Sub Title (in English) | |
| Keyword(1) | IP3 receptor |
| Keyword(2) | phospholipase C |
| Keyword(3) | Ca oscillation |
| Keyword(4) | Endoplasmic reticulum |
| 1st Author's Name | Tatsuo Kitajima |
| 1st Author's Affiliation | Faculty of Engineering Yamagata University() |
| 2nd Author's Name | Yuki Sawai |
| 2nd Author's Affiliation | Faculty of Engineering Yamagata University |
| 3rd Author's Name | Makoto Nishiyama |
| 3rd Author's Affiliation | School of Medicine New York University |
| Date | 2005/3/22 |
| Paper # | NC2004-170 |
| Volume (vol) | vol.104 |
| Number (no) | 759 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |