| Presentation | 2005-05-17 Role of NMDA receptor channels and GABA receptor channels in working memory Tatsuo Kitajima, Satomi Nakui, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | NMDA-receptor channels produce voltage-dependent excitatory postsynaptic potentials and have a critical role in synaptic plasticity such as LTP. Recently, Lisman et al. showed that the voltage dependence of NMDA-receptor mediated EPSPs could produce the selective excitation that is needed to maintain novel items in working memory, by using a network model with recurrent excitatory connections and feedback inhibition mediated by a group of identically connected interneurons. Here, we improve their network model so that one pyramidal neuron excite one GABA-ergic interneuron whose output is given to adjacent pyramidal neurons. By computer simulations based on this modified network model, we analyze in detail the roles for NMDA-receptor channels and GABA-receptor channels in persistent firing activity of pyramidal neurons as working memory. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Working memory / NMDA-receptor channel / GABA-receptor channel / Persistent firing activity |
| Paper # | NLP2005-9 |
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| Committee | NLP |
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| Conference Date | 2005/5/10(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Registration To | Nonlinear Problems (NLP) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Role of NMDA receptor channels and GABA receptor channels in working memory |
| Sub Title (in English) | |
| Keyword(1) | Working memory |
| Keyword(2) | NMDA-receptor channel |
| Keyword(3) | GABA-receptor channel |
| Keyword(4) | Persistent firing activity |
| 1st Author's Name | Tatsuo Kitajima |
| 1st Author's Affiliation | Department of Bio-System Engineering, Faculty of Engineering, Yamagata University() |
| 2nd Author's Name | Satomi Nakui |
| 2nd Author's Affiliation | Department of Bio-System Engineering, Faculty of Engineering, Yamagata University |
| Date | 2005-05-17 |
| Paper # | NLP2005-9 |
| Volume (vol) | vol.105 |
| Number (no) | 49 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |