| Presentation | 2004/11/19 The Change in the role of the activation of NMDA receptor during the carbachol-induced β-oscillation Jun ARAI, Kiyohisa NATSUME, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | The neuronal rhythms in rodents are generated by projection of acetylcholine from medium septum (MS) to hippocampus or by spontaneous oscillaton of inhibitory neuron. The β-oscillations were observed in CA3 region of hippocampal slice in presence of carbachol, one of the cholinergic agonist. I studied what role was the activation of NMDA receptor for β-oscillation in this study. 1) Pre-treatment of 100μM APV, an NMDA receptor antagonist, suppressed the induction of β-oscillation. 2) Once β-oscillation was induced by the applicationn of carbachol, APV decreased the frequency of the oscillation, while in the case with carbachol + bicuculline induced β-oscillation, APV increased the frequency. These results suggest that the activity of NMDA receptor engage the generation of β-oscillation. It is also suggested that GABAergic fibers from MS to hippocampus will modulate the activation of NMDA receptor in hippocampal β-oscillation. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | neuronal rhythm / β-oscillation / NMDA receptor / excitatory synapse / inhibitory synapse |
| Paper # | NLP2004-70,NC2004-86 |
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| Conference Information | |
| Committee | NLP |
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| Conference Date | 2004/11/19(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | Nonlinear Problems (NLP) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | The Change in the role of the activation of NMDA receptor during the carbachol-induced β-oscillation |
| Sub Title (in English) | |
| Keyword(1) | neuronal rhythm |
| Keyword(2) | β-oscillation |
| Keyword(3) | NMDA receptor |
| Keyword(4) | excitatory synapse |
| Keyword(5) | inhibitory synapse |
| 1st Author's Name | Jun ARAI |
| 1st Author's Affiliation | Kyushu Institute of Technology University() |
| 2nd Author's Name | Kiyohisa NATSUME |
| 2nd Author's Affiliation | Kyushu Institute of Technology University |
| Date | 2004/11/19 |
| Paper # | NLP2004-70,NC2004-86 |
| Volume (vol) | vol.104 |
| Number (no) | 471 |
| Page | pp.pp.- |
| #Pages | 5 |
| Date of Issue | |