Presentation 2004/11/19
Synaptic Connection Strength Controlled by Complex Activity of the Hippocampal CA3 Through STDP : A Hippocampal Model
Daisuke SHIMADA, Hatsuo HAYASHI, Motoharu YOSHIDA,
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Abstract(in English) It has been found that plastic change in the synaptic weight depends on the spike-timing of pre and postsynaptic neurons. This is called spike-timing-dependent plasticity (STDP). We will show that connection weight of the Schaffer collateral synapses may be controlled at a proper strength and maintained by complex neuronal activity of CA3 using a hippocampal network model. It is also demonstrated that the connection strength of Schaffer collateral synapses recovers to the augmented state even if the synaptic weight is temporarily disturbed by a periodic perforant path signal as a cue for memory recall.
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Keyword(in English) Hippocampal network model / STDP / Enhancement of Schaffer collateral synapses / Spontaneous activity of CA3
Paper # NLP2004-69,NC2004-85
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Committee NLP
Conference Date 2004/11/19(1days)
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Registration To Nonlinear Problems (NLP)
Language JPN
Title (in Japanese) (See Japanese page)
Sub Title (in Japanese) (See Japanese page)
Title (in English) Synaptic Connection Strength Controlled by Complex Activity of the Hippocampal CA3 Through STDP : A Hippocampal Model
Sub Title (in English)
Keyword(1) Hippocampal network model
Keyword(2) STDP
Keyword(3) Enhancement of Schaffer collateral synapses
Keyword(4) Spontaneous activity of CA3
1st Author's Name Daisuke SHIMADA
1st Author's Affiliation Graduate School of Life Science and System Engineering, Kyushu Institute of Technology()
2nd Author's Name Hatsuo HAYASHI
2nd Author's Affiliation Graduate School of Life Science and System Engineering, Kyushu Institute of Technology
3rd Author's Name Motoharu YOSHIDA
3rd Author's Affiliation Department of Neurology and Neurosurgery, McGill University
Date 2004/11/19
Paper # NLP2004-69,NC2004-85
Volume (vol) vol.104
Number (no) 471
Page pp.pp.-
#Pages 6
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