| Presentation | 2005-06-17 Interrelationship between hydrostatic pressure imposed on and the thickness of the cell layer of a hybrid vascular graft prepared by the method of tissue engineering Lei SUN, Koichi NIWA, Takeshi KARINO, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | The effect of hydrostatic pressure on the growth of the cell layer of a hybrid vascular graft was studied by seeding vascular smooth muscle cells and endothelial cells on an expanded PTFE graft and co-cultivating them under various hydrostatic pressures. It was found that 7 days' exposure of the hybrid graft to hydrostatic pressures of 80, 100, and 120mmHg resulted in remarkable increase in the thickness of the cell layer (an indicative of the proliferation of SMCs) as compared with non-pressurized control. The difference in the thickness of the cell layer was not statistically significant at 80mmHg, but it was significant at 100 and 120 mmHg where the thickness of the cell layer was respectively 116.2% and 74.5% greater than that of control. It was also found that collagen synthesis increased by 24.3, 90.1, and 15.8% at 80, 100, and 120mmHg, respectively, indicating that the cell layer became thicker under elevated hydrostatic pressures not only by the proliferation of SMCs, but also by the increase in the amount of extracellular matrices. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Intimal hyperplasia / Atherosclerosis / Pressure / Smooth muscle cell / Endothelial cell / Cell proliferation |
| Paper # | MBE2005-18 |
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| Conference Information | |
| Committee | MBE |
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| Conference Date | 2005/6/10(1days) |
| Place (in Japanese) | (See Japanese page) |
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| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Interrelationship between hydrostatic pressure imposed on and the thickness of the cell layer of a hybrid vascular graft prepared by the method of tissue engineering |
| Sub Title (in English) | |
| Keyword(1) | Intimal hyperplasia |
| Keyword(2) | Atherosclerosis |
| Keyword(3) | Pressure |
| Keyword(4) | Smooth muscle cell |
| Keyword(5) | Endothelial cell |
| Keyword(6) | Cell proliferation |
| 1st Author's Name | Lei SUN |
| 1st Author's Affiliation | Zhejiang University() |
| 2nd Author's Name | Koichi NIWA |
| 2nd Author's Affiliation | Tokyo Agricultural University |
| 3rd Author's Name | Takeshi KARINO |
| 3rd Author's Affiliation | Research Institute for Electronic Science, Hokkaido University |
| Date | 2005-06-17 |
| Paper # | MBE2005-18 |
| Volume (vol) | vol.105 |
| Number (no) | 122 |
| Page | pp.pp.- |
| #Pages | 4 |
| Date of Issue | |