| Presentation | 2005-06-17 A study on premature ventricular contractions caused by pulsed ultrasound with microbubbles using cultivated cardiac myocytes Goya YOKOYAMA, Kengo OKADA, Nobuki KUDO, Koichi KAWAHARA, Katsuyuki YAMAMOTO, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Recent study in human volunteers has shown that exposure to ultrasound during contrast echocardiography can cause premature ventricular contractions (PVCs). To elucidate its mechanism, we carried out experiments using cultivated cardiac myocytes and investigated the dependence of PVC production on timing and pressure amplitude of ultrasound irradiation with and without microbubbles. In the results, PVCs were observed only in the period after the end of myocyte contraction, suggesting that this time-dependent phenomenon was caused by a refractory period of myocytes. Threshold pressure to produce PVCs decreased in the presence of microbubbles attached to the cells, reflecting that the ultrasound-induced bubble behavior can give mechanical stress to myocytes greater than that produced by exposure to ultrasound without microbubbles. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | ultrasound contrast agent / adverse effect / microbubbles / contrast echocardiography / premature ventricular contraction |
| Paper # | MBE2005-16 |
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| Conference Information | |
| Committee | MBE |
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| Conference Date | 2005/6/10(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
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| Vice Chair | |
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| Paper Information | |
| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | A study on premature ventricular contractions caused by pulsed ultrasound with microbubbles using cultivated cardiac myocytes |
| Sub Title (in English) | |
| Keyword(1) | ultrasound contrast agent |
| Keyword(2) | adverse effect |
| Keyword(3) | microbubbles |
| Keyword(4) | contrast echocardiography |
| Keyword(5) | premature ventricular contraction |
| 1st Author's Name | Goya YOKOYAMA |
| 1st Author's Affiliation | Graduate School of Information Science and Technology, Hokkaido University() |
| 2nd Author's Name | Kengo OKADA |
| 2nd Author's Affiliation | Graduate School of Information Science and Technology, Hokkaido University |
| 3rd Author's Name | Nobuki KUDO |
| 3rd Author's Affiliation | Graduate School of Information Science and Technology, Hokkaido University |
| 4th Author's Name | Koichi KAWAHARA |
| 4th Author's Affiliation | Graduate School of Information Science and Technology, Hokkaido University |
| 5th Author's Name | Katsuyuki YAMAMOTO |
| 5th Author's Affiliation | Graduate School of Information Science and Technology, Hokkaido University |
| Date | 2005-06-17 |
| Paper # | MBE2005-16 |
| Volume (vol) | vol.105 |
| Number (no) | 122 |
| Page | pp.pp.- |
| #Pages | 4 |
| Date of Issue | |