| Presentation | 2004/5/21 Neural mechanism of transcranial magnetic stimulation: spike inhibition in a recurrent cortical network Yoichi MIYAWAKI, Masato OKADA, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | We propose mechanisms of neural interference induced by transcranial magnetic stimulation (TMS). TMS is widely used as a powerful and unique experimental tool to stimulate the human brain noinvasively, which typically induces inhibitory effect on the cortical functions. However, the fundamental neural mechanism of TMS-induced suppression is still unclear, even though twenty years have passed science the first TMS technique has developped. In this paper, we assume TMS as an brief perturbation that is uniformly applied onto a neural population, and computationally analyze the mechanism of TMS-induced suppression. Here, in particular, we employed a conductance-based recurrent network model exhibiting feature selectivity in the cortex. We demonstrate that the TMS-like perturbation induces sustained spike inhibition in the network without the ion channel which is necessary for spike inhibition in an isolated single neuron, suggesting that each individual neuron is not necessarily suppressed by TMS; rather, a collapse of excitatory and inhibitory input balance in the cortical network is crucial for TMS-induced suppression. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | TMS / Spike inhibition / Conductance-based model / Perturbation / AHP channel |
| Paper # | NC2004-10 |
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| Committee | NC |
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| Conference Date | 2004/5/21(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | Neurocomputing (NC) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Neural mechanism of transcranial magnetic stimulation: spike inhibition in a recurrent cortical network |
| Sub Title (in English) | |
| Keyword(1) | TMS |
| Keyword(2) | Spike inhibition |
| Keyword(3) | Conductance-based model |
| Keyword(4) | Perturbation |
| Keyword(5) | AHP channel |
| 1st Author's Name | Yoichi MIYAWAKI |
| 1st Author's Affiliation | PRESTO, JST/RIKEN Brain Science Institute() |
| 2nd Author's Name | Masato OKADA |
| 2nd Author's Affiliation | PRESTO, JST/RIKEN Brain Science Institute |
| Date | 2004/5/21 |
| Paper # | NC2004-10 |
| Volume (vol) | vol.104 |
| Number (no) | 99 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |