| Presentation | 1997/10/9 Surface Design by Cell-recognizable Glycopolymers and its Application to Biomedical Engineering Toshihiro Akaike, |
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| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Surface design of protein-like polymers for cellular and tissue engineering needs lots of analysis about not only surface characteristics but also extracellular matrices and cytokines network which play important roles for the regulation of cellular function. In order to develop high performance artificial livers, we designed a superglycoprotein-like polymer (PVLA) as a specific model ligand to asialoglycoprotein receptors (ASGP-R) on hepatocytes and examined interfacial phenomena of the polymer. Hepatocytes morphology was remarkably affected by PVLA concentration for coating on polystyrene dishes. In addition, hepatic functions such as differentiation and proliferation were closely related with cell morphology. Especially, round hepatocytes on the polystyrene surface coated with high concentration of PVLA were found to reconstruct 3D liver-like tissue stimulated by EGF. It turned out that the adsorptive states of PVLA polymeric micells can switch the function of EGF to be motogenic or mitogenic. The mechanisms of 3D tissue formation on two types of substrata mediated by ASGP-R will be discussed. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Surface / asialoglycoprotein / eztracellular matrix / hepatocyte / tissue-engineering / glycopolymer |
| Paper # | OME97-78-81 |
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| Conference Information | |
| Committee | OME |
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| Conference Date | 1997/10/9(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | Organic Material Electronics (OME) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Surface Design by Cell-recognizable Glycopolymers and its Application to Biomedical Engineering |
| Sub Title (in English) | |
| Keyword(1) | Surface |
| Keyword(2) | asialoglycoprotein |
| Keyword(3) | eztracellular matrix |
| Keyword(4) | hepatocyte |
| Keyword(5) | tissue-engineering |
| Keyword(6) | glycopolymer |
| 1st Author's Name | Toshihiro Akaike |
| 1st Author's Affiliation | Department of Biomolecular Engineering, Tokyo Institute of Technology() |
| Date | 1997/10/9 |
| Paper # | OME97-78-81 |
| Volume (vol) | vol.97 |
| Number (no) | 308 |
| Page | pp.pp.- |
| #Pages | 9 |
| Date of Issue | |