Presentation 1997/6/27
Surface Design for Improvement of Sensitivity of Surface Plasmon Resonance-Based Immunosensor
Shigeru Toyama, Sachiko Ichikawa, Yoshihito Ikariyama,
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Abstract(in Japanese) (See Japanese page)
Abstract(in English) To improve densitivity of surface plasmon resonance(SPR)-based immunosensor, several methods of immobilizing antigen on gold vaporized substrate were examined. Human albumin was immobilized on the surface of such a gold film mounted on a prism in a flow injection system. And the resonance angle upon anti-human albumin injection was measued. As a result, covalent immobilization method was turned out superior to physical immobilization. Also, hydrophilic polymers such as hydrxyethylstarch or sulfuric dextran as a matrix for antigen immobilization exhibited repeated detection when the antigen was treated with NaBH_4 reduction.
Keyword(in Japanese) (See Japanese page)
Keyword(in English) SPR / immunosensor / hydroxyethylstarch / sulfuric dextran / Shiff's base
Paper # CPM97-29
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Committee OME
Conference Date 1997/6/27(1days)
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Registration To Organic Material Electronics (OME)
Language JPN
Title (in Japanese) (See Japanese page)
Sub Title (in Japanese) (See Japanese page)
Title (in English) Surface Design for Improvement of Sensitivity of Surface Plasmon Resonance-Based Immunosensor
Sub Title (in English)
Keyword(1) SPR
Keyword(2) immunosensor
Keyword(3) hydroxyethylstarch
Keyword(4) sulfuric dextran
Keyword(5) Shiff's base
1st Author's Name Shigeru Toyama
1st Author's Affiliation Research Institute, National Rehabilitation Center for the Disabled()
2nd Author's Name Sachiko Ichikawa
2nd Author's Affiliation Research Institute, National Rehabilitation Center for the Disabled
3rd Author's Name Yoshihito Ikariyama
3rd Author's Affiliation Research Institute, National Rehabilitation Center for the Disabled
Date 1997/6/27
Paper # CPM97-29
Volume (vol) vol.97
Number (no) 144
Page pp.pp.-
#Pages 6
Date of Issue