| Presentation | 2002/3/12 Emergent mechanisms of sustained and transient cardiac alternans Yoshiaki NAKAO, Taishin NOMURA, Shunsuke SATO, Gentaro IRIBE, Junichi ARAKI, Fumihiko KAJIYA, |
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| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | The cardiac alternans, in which two different ECG waveforms alternate in beat-to-beat basis, has been considered as a significant index of vulnerability of the heart to ventricular arrhythmias. When the alternans is damping out soon after its onset, it is called transient alternans. Isolated ventricular heart cells can also exhibit both sustained and transient alternans. In this study, a detailed mathematical model of ventricular cells (Winslow's model) was utilized to understand the emergent mechanism of these two types of alternans. To this end, first, we showed that the model could well reproduce the sustained and transient alternans. Detailed analyses of the model's dynamics suggested that the period-doubling bifurcation, a typical bifurcation phenomenon inherent to nonlinear dynamical systems, plays an important role for the emergence of the cardiac alternans. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | alternans / arrhythmia / mathematical model / nonlinear dynamics / period-doubling bifurcation |
| Paper # | MBE2001-193 |
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| Conference Information | |
| Committee | MBE |
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| Conference Date | 2002/3/12(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Emergent mechanisms of sustained and transient cardiac alternans |
| Sub Title (in English) | |
| Keyword(1) | alternans |
| Keyword(2) | arrhythmia |
| Keyword(3) | mathematical model |
| Keyword(4) | nonlinear dynamics |
| Keyword(5) | period-doubling bifurcation |
| 1st Author's Name | Yoshiaki NAKAO |
| 1st Author's Affiliation | Department of Systems and Human Science, Graduate School of Engineering Science, Osaka University() |
| 2nd Author's Name | Taishin NOMURA |
| 2nd Author's Affiliation | Department of Systems and Human Science, Graduate School of Engineering Science, Osaka University |
| 3rd Author's Name | Shunsuke SATO |
| 3rd Author's Affiliation | Department of Systems and Human Science, Graduate School of Engineering Science, Osaka University |
| 4th Author's Name | Gentaro IRIBE |
| 4th Author's Affiliation | Department of Physiology II, Okayama University Medical School |
| 5th Author's Name | Junichi ARAKI |
| 5th Author's Affiliation | Department of Physiology II, Okayama University Medical School |
| 6th Author's Name | Fumihiko KAJIYA |
| 6th Author's Affiliation | Department of Physiology II, Okayama University Medical School |
| Date | 2002/3/12 |
| Paper # | MBE2001-193 |
| Volume (vol) | vol.101 |
| Number (no) | 734 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |