| Presentation | 2001/11/22 A Multi-oscillator Model of Methamphetamine-induced Circadian Phythms Nobuko TOKUMARU, Mitsuyuki NAKAO, Norihiro KATAYAMA, MItsuaki YAMAMOTO, |
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| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Administration of methamphetamine(MAP)is known to induce behavioral rhythm in rats independent of suprachiasmatic nucleus(MAP-induced rhythm), which is regarded as a possible candidate of circadian oscillator driving an overt activity rhythm. Here, in order to investigate underlying mechanism of rhythm generation and its dynamics, a model consisting of mutually coupled multiple Bonhoeffer-Van del Pol(BVP)oscillators was constructed. As a result, both of limit cycle and damping oscillator models reproduced MAP concentration-dependency of oscillation parameters such as α/ρ ratio. Haloperidol, non-selective antagonist of dopamine, induced phase shift of the MAP-induced rhythm was qualitatively reproduced only by the damping oscillator-coupled model. Therefore, coupled-multiple damping oscillator is suggested to be plausible as a generation mechanism of MAP-induced rhythm/ |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Circadian rhythm / Methamphetamine / Haloperidol / BVP oscillator |
| Paper # | MBE2001-105 |
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| Conference Information | |
| Committee | MBE |
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| Conference Date | 2001/11/22(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
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| Vice Chair | |
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| Paper Information | |
| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | A Multi-oscillator Model of Methamphetamine-induced Circadian Phythms |
| Sub Title (in English) | |
| Keyword(1) | Circadian rhythm |
| Keyword(2) | Methamphetamine |
| Keyword(3) | Haloperidol |
| Keyword(4) | BVP oscillator |
| 1st Author's Name | Nobuko TOKUMARU |
| 1st Author's Affiliation | Neurophysiology and Bioinformatics Laboratory, Graduate School of Information Sciences, Tohoku University() |
| 2nd Author's Name | Mitsuyuki NAKAO |
| 2nd Author's Affiliation | Neurophysiology and Bioinformatics Laboratory, Graduate School of Information Sciences, Tohoku University |
| 3rd Author's Name | Norihiro KATAYAMA |
| 3rd Author's Affiliation | Neurophysiology and Bioinformatics Laboratory, Graduate School of Information Sciences, Tohoku University |
| 4th Author's Name | MItsuaki YAMAMOTO |
| 4th Author's Affiliation | Neurophysiology and Bioinformatics Laboratory, Graduate School of Information Sciences, Tohoku University |
| Date | 2001/11/22 |
| Paper # | MBE2001-105 |
| Volume (vol) | vol.101 |
| Number (no) | 478 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |