| Presentation | 2001/6/15 Phosphate Metabolites measured by ^<31>P-MR Spectroscopy in Mild Hypothermic brain following Transient Forebrain Ischemia in Gerbil T. Kimura, K. Tanaka, K. Sako, M. Kusakabe, T. Tanaka, Takahashi T, T. Nakada, |
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| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | High-energy phosphate metabolism (ATP, PCr, Pi) and intracellular pH were sequentially measured with gerbil (50-60g) with a transient (15 min.) bilateral carotid artery occlusion models using ^<31>P-MRS during ischemia and after reperfusion in mild hypothermic (34℃ n=10) and normothermic (37℃ n=10) group for 1 week. They were also evaluated by histopathology. During ischemia there were no statistically significant differences in any metabolites in both groups. However, after the reperfusion, metabolic recovery of mild hypothermic group was significantly faster and about 10-20% higher than in normothermic group. One week after ischemia, energy metabolism was gradually decreased about 10-20 % in both groups. In histopathology, pyramidal cell damage in hippocampus was 35 % in average in mild hypothermia, and 82 % in normothermia. The neuronal damage in cerebral cortex was 24 % in mild hypothermia, and 59 % in normothermia. The results of the present experiment imply that the protective effect of mild hypothermia is due to the high recovery rate of ATP and PCr and the prevention of 2nd decline of high phosphate energy. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | mild hypothermia / transient ischemia / global ischemia / redox state recovery / mitochondria / ^<31>P-MRS |
| Paper # | MBE2001-32 |
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| Conference Information | |
| Committee | MBE |
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| Conference Date | 2001/6/15(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
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| Paper Information | |
| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Phosphate Metabolites measured by ^<31>P-MR Spectroscopy in Mild Hypothermic brain following Transient Forebrain Ischemia in Gerbil |
| Sub Title (in English) | |
| Keyword(1) | mild hypothermia |
| Keyword(2) | transient ischemia |
| Keyword(3) | global ischemia |
| Keyword(4) | redox state recovery |
| Keyword(5) | mitochondria |
| Keyword(6) | ^<31>P-MRS |
| 1st Author's Name | T. Kimura |
| 1st Author's Affiliation | Department of Neurosurgery, Asahikawa Medical College:Department of Integrated Neuroscience, University of Niigata() |
| 2nd Author's Name | K. Tanaka |
| 2nd Author's Affiliation | Central Laboratory for Research and Education, Asahikawa Medical College |
| 3rd Author's Name | K. Sako |
| 3rd Author's Affiliation | Department of Neurosurgery, Asahikawa Medical College |
| 4th Author's Name | M. Kusakabe |
| 4th Author's Affiliation | Central Laboratory for Research and Education, Asahikawa Medical College |
| 5th Author's Name | T. Tanaka |
| 5th Author's Affiliation | Department of Neurosurgery, Asahikawa Medical College |
| 6th Author's Name | Takahashi T |
| 6th Author's Affiliation | Department of Pathology, Brain Research Institute, University of Niigata |
| 7th Author's Name | T. Nakada |
| 7th Author's Affiliation | Department of Integrated Neuroscience, University of Niigata |
| Date | 2001/6/15 |
| Paper # | MBE2001-32 |
| Volume (vol) | vol.101 |
| Number (no) | 130 |
| Page | pp.pp.- |
| #Pages | 8 |
| Date of Issue | |