| Presentation | 2001/6/15 Basic Studies on Dynamic Behaviors of Microbubbles Exposed to Ultrasound : Mechanical Effects for Biological Tissue Takehiro MIYAOKA, Junji FURUYA, Nobuki KUOD, Kouichi NIWA, Katsuyuki YAMAMOTO, |
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| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Recently, it has been reported that activation of contrast agent gas bodies by ultrasound exposure can damage the cell membrane. To elucidate mechanisms of such cell damage, we improved an high-speed and high-magnification observation system using a new high-speed camera and an inverted microscope. microbubbles of 3 to several tens microns in diameter were exposed to 1 MHz or 250 kHz ultrasound, and their dynamic behaviors were observed in 24-frame sequential high-speed photographs at the maximum frame rate of 8 million frames per second. Typical movements of a bubble, such as rapid contraction resulting in destruction of the microbubble and non-uniform contraction accompanied with generation of a small stream, were observed. To study the possibility that these bubble movements can cause cell damage, bovine arterial endothelial cells and microbubbles were exposed to ultrasound. Non-uniform contraction of a microbubble and deformation of the cell beside the bubble were observed. It was suggested that a small stream generated by non-uniform contraction of a bubble could cause mechanical damage to a cell. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Ultrasonography / Contrast agents / High-speed photography / Microbubble / Mechanical Effects |
| Paper # | MBE2001-30 |
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| Conference Information | |
| Committee | MBE |
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| Conference Date | 2001/6/15(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
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| Vice Chair | |
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| Paper Information | |
| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Basic Studies on Dynamic Behaviors of Microbubbles Exposed to Ultrasound : Mechanical Effects for Biological Tissue |
| Sub Title (in English) | |
| Keyword(1) | Ultrasonography |
| Keyword(2) | Contrast agents |
| Keyword(3) | High-speed photography |
| Keyword(4) | Microbubble |
| Keyword(5) | Mechanical Effects |
| 1st Author's Name | Takehiro MIYAOKA |
| 1st Author's Affiliation | Graduate School of Engneering, Hokkaido University() |
| 2nd Author's Name | Junji FURUYA |
| 2nd Author's Affiliation | Graduate School of Engneering, Hokkaido University |
| 3rd Author's Name | Nobuki KUOD |
| 3rd Author's Affiliation | Graduate School of Engneering, Hokkaido University |
| 4th Author's Name | Kouichi NIWA |
| 4th Author's Affiliation | Research Institute for Electronic Science Hokkaido University |
| 5th Author's Name | Katsuyuki YAMAMOTO |
| 5th Author's Affiliation | Graduate School of Engneering, Hokkaido University |
| Date | 2001/6/15 |
| Paper # | MBE2001-30 |
| Volume (vol) | vol.101 |
| Number (no) | 130 |
| Page | pp.pp.- |
| #Pages | 7 |
| Date of Issue | |