| Presentation | 2001/1/20 Statistical analysis of gene expression patterns by graphical models Tetsuya Matsuno, Nobuaki Tominaga, |
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| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Gene expression patterns of nematodes(C.elegans)were statistically analysed by the method of graphical modelling. The investigated expression patterns were obtained by using the DNA microarray technology. Graphical modelling provides an association structure among variables(genes)under consideration. The method produces a most plausible reduced model constructed from a correlation matrix of the variables observed. The reduced model is depicted by what is called an independence graph, which shows an association structure representing characteristics of conditional independence among variables. We assumed that a correlation of behaviors of genes was due to a common factor for control of transcriptions for the genes. A signal transduction structure was reconstructed based on the above assumption together with the resultant independence graph. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Graphical model / Conditional independence / Independence graph / Gene expression / DNA microarray |
| Paper # | MBE2000-144 |
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| Conference Information | |
| Committee | MBE |
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| Conference Date | 2001/1/20(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
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| Paper Information | |
| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Statistical analysis of gene expression patterns by graphical models |
| Sub Title (in English) | |
| Keyword(1) | Graphical model |
| Keyword(2) | Conditional independence |
| Keyword(3) | Independence graph |
| Keyword(4) | Gene expression |
| Keyword(5) | DNA microarray |
| 1st Author's Name | Tetsuya Matsuno |
| 1st Author's Affiliation | Dept.Electronics and Information Engineering, Ariake National College of Technology() |
| 2nd Author's Name | Nobuaki Tominaga |
| 2nd Author's Affiliation | Dept.Chemical Science and Engineering, Ariake National College of Technology |
| Date | 2001/1/20 |
| Paper # | MBE2000-144 |
| Volume (vol) | vol.100 |
| Number (no) | 599 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |