Presentation 2000/11/23
Long-term potentiation of synaptically activated increases in calcium concentration in hippocampal dentate dyrus cells
Masato OZAWA, Norihiro KATAYAMA, Mitsuyuki NAKAO, Mitsuaki YAMAMOTO,
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Abstract(in English) Intracellular Ca^2+ is known to play important role for regulation and control of many cellular chemical processes. In this study, increase in intracellular Ca^2+ concentration(△[Ca^2+])evoked by a burst stimulation (20Hz, 5pulses)to perforant path(PP)synapses were measured in dentate granule cells of rat hippocampal slices by means of laser scanning microscope. After a tetanic stimulation(100Hz, 100pulses)to the PP-synapses, some cells showed increase in △[Ca^2+]evoked by PP-synaptic inputs for 1 hour. Since the △[Ca^2+]is known to associated with the firing of granule cells, the result is expected to reflect the increase of firing probabirily of the cells in response to the synaptic inputs caused by the long-term potentiation at the synapses.
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Keyword(in English) neuron / hippocampus / Long-term potentiation / calcium imaging / laser scanning microscope
Paper # MBE2000-94
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Conference Information
Committee MBE
Conference Date 2000/11/23(1days)
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Paper Information
Registration To ME and Bio Cybernetics (MBE)
Language JPN
Title (in Japanese) (See Japanese page)
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Title (in English) Long-term potentiation of synaptically activated increases in calcium concentration in hippocampal dentate dyrus cells
Sub Title (in English)
Keyword(1) neuron
Keyword(2) hippocampus
Keyword(3) Long-term potentiation
Keyword(4) calcium imaging
Keyword(5) laser scanning microscope
1st Author's Name Masato OZAWA
1st Author's Affiliation Graduate School of Information Sciences, Tohoku University()
2nd Author's Name Norihiro KATAYAMA
2nd Author's Affiliation Graduate School of Information Sciences, Tohoku University
3rd Author's Name Mitsuyuki NAKAO
3rd Author's Affiliation Graduate School of Information Sciences, Tohoku University
4th Author's Name Mitsuaki YAMAMOTO
4th Author's Affiliation Graduate School of Information Sciences, Tohoku University
Date 2000/11/23
Paper # MBE2000-94
Volume (vol) vol.100
Number (no) 478
Page pp.pp.-
#Pages 7
Date of Issue