Presentation | 1999/3/19 Apoptosis-like cell death in cultured cardiac myocytes from neonatal rats Taiga Satoh, Yoshiko Yamauchi, Hideomi Sato, Koichi Kawahara, |
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Abstract(in Japanese) | (See Japanese page) |
Abstract(in English) | This study showed that de nevo protein synthesis inhibitor, cycloheximide (CHX) induced cardiomyocyte-specific apoptosis-like cell death in cardiac myocyte-fibroblast co-cultures from neonatal rats. Such cardiomyocyle death was characterized by the shrinkage of cell body, the formation of DNA fragment, and by the condensation of nuclear chromatin. CHX-induced apoptosis-like myocyte death was suppressed by the caspase-3 inhibitor and the inhibitor of Na^+/H^+ antiporter, amiloride. There results suggest a possible involvement of caspase-3 activation and Na^+/H^+ antiporter activation in the apoptosis-signal transduction cascade of cardiomyocytes. |
Keyword(in Japanese) | (See Japanese page) |
Keyword(in English) | cardiomyocyte / apoptosis / cycloheximide / caspase-3 |
Paper # | MBE98-150 |
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Conference Information | |
Committee | MBE |
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Conference Date | 1999/3/19(1days) |
Place (in Japanese) | (See Japanese page) |
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Topics (in Japanese) | (See Japanese page) |
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Paper Information | |
Registration To | ME and Bio Cybernetics (MBE) |
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Language | JPN |
Title (in Japanese) | (See Japanese page) |
Sub Title (in Japanese) | (See Japanese page) |
Title (in English) | Apoptosis-like cell death in cultured cardiac myocytes from neonatal rats |
Sub Title (in English) | |
Keyword(1) | cardiomyocyte |
Keyword(2) | apoptosis |
Keyword(3) | cycloheximide |
Keyword(4) | caspase-3 |
1st Author's Name | Taiga Satoh |
1st Author's Affiliation | Research Institute for Electronic Science, Hokkaido University() |
2nd Author's Name | Yoshiko Yamauchi |
2nd Author's Affiliation | Research Institute for Electronic Science, Hokkaido University |
3rd Author's Name | Hideomi Sato |
3rd Author's Affiliation | Research Institute for Electronic Science, Hokkaido University |
4th Author's Name | Koichi Kawahara |
4th Author's Affiliation | Research Institute for Electronic Science, Hokkaido University |
Date | 1999/3/19 |
Paper # | MBE98-150 |
Volume (vol) | vol.98 |
Number (no) | 672 |
Page | pp.pp.- |
#Pages | 6 |
Date of Issue |