| Presentation | 1999/3/19 Apoptosis-like cell death in cultured cardiac myocytes from neonatal rats Taiga Satoh, Yoshiko Yamauchi, Hideomi Sato, Koichi Kawahara, |
|---|---|
| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | This study showed that de nevo protein synthesis inhibitor, cycloheximide (CHX) induced cardiomyocyte-specific apoptosis-like cell death in cardiac myocyte-fibroblast co-cultures from neonatal rats. Such cardiomyocyle death was characterized by the shrinkage of cell body, the formation of DNA fragment, and by the condensation of nuclear chromatin. CHX-induced apoptosis-like myocyte death was suppressed by the caspase-3 inhibitor and the inhibitor of Na^+/H^+ antiporter, amiloride. There results suggest a possible involvement of caspase-3 activation and Na^+/H^+ antiporter activation in the apoptosis-signal transduction cascade of cardiomyocytes. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | cardiomyocyte / apoptosis / cycloheximide / caspase-3 |
| Paper # | MBE98-150 |
| Date of Issue |
| Conference Information | |
| Committee | MBE |
|---|---|
| Conference Date | 1999/3/19(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Chair | |
| Vice Chair | |
| Secretary | |
| Assistant | |
| Paper Information | |
| Registration To | ME and Bio Cybernetics (MBE) |
|---|---|
| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Apoptosis-like cell death in cultured cardiac myocytes from neonatal rats |
| Sub Title (in English) | |
| Keyword(1) | cardiomyocyte |
| Keyword(2) | apoptosis |
| Keyword(3) | cycloheximide |
| Keyword(4) | caspase-3 |
| 1st Author's Name | Taiga Satoh |
| 1st Author's Affiliation | Research Institute for Electronic Science, Hokkaido University() |
| 2nd Author's Name | Yoshiko Yamauchi |
| 2nd Author's Affiliation | Research Institute for Electronic Science, Hokkaido University |
| 3rd Author's Name | Hideomi Sato |
| 3rd Author's Affiliation | Research Institute for Electronic Science, Hokkaido University |
| 4th Author's Name | Koichi Kawahara |
| 4th Author's Affiliation | Research Institute for Electronic Science, Hokkaido University |
| Date | 1999/3/19 |
| Paper # | MBE98-150 |
| Volume (vol) | vol.98 |
| Number (no) | 672 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |