| Presentation | 1998/6/19 Long-lasting intracellular calcium elevation causes neuronal death in neuron-astrocyte co-cultures Hideomi SATO, Junji HORI, Yoshiaki HABARA, Koichi KAWAHARA, |
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| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | We have demonstrated that glutamate-induced neuronal death is probably caused by long-lasting intracellular calcium elevation mediated by the activation of NMDA receptors in neuron-astrocyte co-cultures. To elucidate the mechanisms underlying this glutamate toxicity, we investigated the survival rate of neurons 24 hours after administration of calcium ionophore for mimicking long-lasting calcium elevation observed during glutamate loading. Loading of calcium ionophore resulted in the long-lasting intracellular calcium increase in neurons, and induced neuronal death. These results suggested that the long-lasting intracellular calcium elevation is crucial for the glutamate-induced neuronal death. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | neurotoxicity / glutamate / intracellular calcium / calcium ionophore / NMDA receptor |
| Paper # | MBE98-27 |
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| Committee | MBE |
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| Conference Date | 1998/6/19(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Long-lasting intracellular calcium elevation causes neuronal death in neuron-astrocyte co-cultures |
| Sub Title (in English) | |
| Keyword(1) | neurotoxicity |
| Keyword(2) | glutamate |
| Keyword(3) | intracellular calcium |
| Keyword(4) | calcium ionophore |
| Keyword(5) | NMDA receptor |
| 1st Author's Name | Hideomi SATO |
| 1st Author's Affiliation | Research Institute for Electronic Science, Hokkaido University() |
| 2nd Author's Name | Junji HORI |
| 2nd Author's Affiliation | Research Institute for Electronic Science, Hokkaido University |
| 3rd Author's Name | Yoshiaki HABARA |
| 3rd Author's Affiliation | Graduate School of Veterinary Medicine, Hokkaido University |
| 4th Author's Name | Koichi KAWAHARA |
| 4th Author's Affiliation | Research Institute for Electronic Science, Hokkaido University |
| Date | 1998/6/19 |
| Paper # | MBE98-27 |
| Volume (vol) | vol.98 |
| Number (no) | 135 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |