| Presentation | 1998/5/29 Simulation Analysis of Transient Phase of Gene Transcription. H Hirayama, Y Okita, |
|---|---|
| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | We analyzed transient changes of the dynamic activation processes of genes by numerical computational technique. The model is extended version of that proposed by Manabe(1981). The sequence of genes are composed of regulatory region, control region composed of the promoter and operator regions. The repressor when bound to the operator region inhibits the starting of transcription by RNA polymerase. When the repressor was caught by an inducer, the repressor is released from the operator gene and transcription starts. We have set the amount of repressor, inducer and RNA polyumerase as variables and described these activation sequence by 16 non linear differential equations. The rate constants were utilized from reported experimental data. The temporal changes of the species showed a characteristic pattern. The present modeling will be available for predicting the dynamic behavior of the gene activation process. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Gene / Repressor / Inducer / Operator / Promoter / RNA polymerase / Transcription / Non linear |
| Paper # | |
| Date of Issue |
| Conference Information | |
| Committee | MBE |
|---|---|
| Conference Date | 1998/5/29(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Chair | |
| Vice Chair | |
| Secretary | |
| Assistant | |
| Paper Information | |
| Registration To | ME and Bio Cybernetics (MBE) |
|---|---|
| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Simulation Analysis of Transient Phase of Gene Transcription. |
| Sub Title (in English) | |
| Keyword(1) | Gene |
| Keyword(2) | Repressor |
| Keyword(3) | Inducer |
| Keyword(4) | Operator |
| Keyword(5) | Promoter |
| Keyword(6) | RNA polymerase |
| Keyword(7) | Transcription |
| Keyword(8) | Non linear |
| 1st Author's Name | H Hirayama |
| 1st Author's Affiliation | Department of Public Health Asahikawa Medical College.() |
| 2nd Author's Name | Y Okita |
| 2nd Author's Affiliation | National Institute of Special Education.Yokosuka |
| Date | 1998/5/29 |
| Paper # | |
| Volume (vol) | vol.98 |
| Number (no) | 94 |
| Page | pp.pp.- |
| #Pages | 8 |
| Date of Issue | |