| Presentation | 1995/7/22 Comparative effects of hypotension by isoflurane, nitroglycerin and adenosine on subendocardial microvessel diameter : Observation of the in situ beating swine ventricle under critical stenosis Yoshihisa Fujita, Helmut Habazettl, Calros O. Corso, Konrad Messmer, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | We performed this study to determine whether isoflurane-induced hypotension may cause subendocardial ischemia of the heart with proximal coronary stenosis. Regional myocardial function, oxygen supply/demand, lactate production and subendocardial microvessels were evaluated under isoflurane-, adenosine- or nitroglycerin- induced hypotension (mean arterial pressure at about 55mmHg) in swine beating hearts with a fixed critical stenosis of the left anterior descending coronary artery (LD). Regional myocardial lactate production from the LAD perfused area and coronary sinus PO_2 suggested preserved myocardial perfusion with isoflurane compared to the condition with adenosine. Subendocardial microscopy revealed a phasic diameter changes of subendocardial microvessels with cardiac cycles under isoflurane or nitroglycerin, while no consistent phasic diameter changes was evident with adenosine. These findings suggest that subendocardial microcirculation is relatively preserved under isoflurane adenosine-induced hypotension, and that transmural steal does not occur with isoflurane. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | isoflurane / adenosine / nitroglycerin / subendocardial microcirculation / videomicroscpoe |
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| Conference Information | |
| Committee | MBE |
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| Conference Date | 1995/7/22(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Comparative effects of hypotension by isoflurane, nitroglycerin and adenosine on subendocardial microvessel diameter : Observation of the in situ beating swine ventricle under critical stenosis |
| Sub Title (in English) | |
| Keyword(1) | isoflurane |
| Keyword(2) | adenosine |
| Keyword(3) | nitroglycerin |
| Keyword(4) | subendocardial microcirculation |
| Keyword(5) | videomicroscpoe |
| 1st Author's Name | Yoshihisa Fujita |
| 1st Author's Affiliation | Department of Anesthesiology, Kawasaki Medical School() |
| 2nd Author's Name | Helmut Habazettl |
| 2nd Author's Affiliation | The Institute for Surgical Research, Klinikum Grosshadern, Ludwig-Maximilians University |
| 3rd Author's Name | Calros O. Corso |
| 3rd Author's Affiliation | The Institute for Surgical Research, Klinikum Grosshadern, Ludwig-Maximilians University |
| 4th Author's Name | Konrad Messmer |
| 4th Author's Affiliation | The Institute for Surgical Research, Klinikum Grosshadern, Ludwig-Maximilians University |
| Date | 1995/7/22 |
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| Volume (vol) | vol.95 |
| Number (no) | 177 |
| Page | pp.pp.- |
| #Pages | 6 |
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