| Presentation | 1996/6/20 Linear System Analysis of Behavior of Calcium Ion Receptor by an Allosteric Model H Tamura, H Hirayama, T Nishimura, Y. Fukuyama, |
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| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Linear system analysis was applied for calcium currents in A7r5 smooth muscle cell. The conformal changes of calcium channel activation was expressed by a Monod-Wyman-Changeux allosteric model with four homologous domains in the main subunit of the calcium channel. The movement of a voltage sensor in the model was analogous to ligand binding, the closed and open channels correspond to inactive (T) and active (R) states of the model. The linear system analysis disclosed that the system is stable but uncontrollable. The impulse responses of channels between the open and closed state with the same number of activated voltage sensors were parallel. The present method is available for evaluating the dynamic functional properties of calcium channel. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Calcium channel / MWC allosteric model / Ligand / Linear system / Stability / Controllability |
| Paper # | MBE96-33 |
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| Conference Information | |
| Committee | MBE |
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| Conference Date | 1996/6/20(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Chair | |
| Vice Chair | |
| Secretary | |
| Assistant | |
| Paper Information | |
| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | ENG |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Linear System Analysis of Behavior of Calcium Ion Receptor by an Allosteric Model |
| Sub Title (in English) | |
| Keyword(1) | Calcium channel |
| Keyword(2) | MWC allosteric model |
| Keyword(3) | Ligand |
| Keyword(4) | Linear system |
| Keyword(5) | Stability |
| Keyword(6) | Controllability |
| 1st Author's Name | H Tamura |
| 1st Author's Affiliation | Department of Public health, Asahikawa medical college() |
| 2nd Author's Name | H Hirayama |
| 2nd Author's Affiliation | Department of Public health, Asahikawa medical college |
| 3rd Author's Name | T Nishimura |
| 3rd Author's Affiliation | Department of Electrical and Electronical Engineering, Oita university |
| 4th Author's Name | Y. Fukuyama |
| 4th Author's Affiliation | Department of Public health, Asahikawa medical college |
| Date | 1996/6/20 |
| Paper # | MBE96-33 |
| Volume (vol) | vol.96 |
| Number (no) | 113 |
| Page | pp.pp.- |
| #Pages | 8 |
| Date of Issue | |