| Presentation | 1998/3/19 Glutamate-induced neurotoxicity in neuron-astrocyte co-cultures from the embryonic rat cortex Junji Hori, Hideomi Sato, Yoshiyasu Kobayashi, Kazuo Nagashima, Yoshiaki Habara, Koichi Kawahara, |
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| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Exposure of neuron-astrocyte co-cultures from the embryonic rat cortex to glutamate (Glu) resulted in neuronal death which was preceded by a long-lasting increase in intracellular Ca^<2+> concentration. Administration of (±)2-Amino-5-phosphonopentamicacid(AP5) protected the cells against neuronal death caused by Glu, suggesting that Glu-induced neuronal death and the long-lasting increase in intracellular Ca^<2+> concentration seem to be mediated by the activation of N-methy-D-aspartate(NMDA) receptors. Administration of dihydrokainate(DHK), an artrocytes'Glu-uptake inhibitor, resulted in exaggerated neuronal death even in the physiological level of extracellular Glu concentration. This result suggests that the Glu-transporter of astrocytes plays an important functional role in the protection of neurons against Glu toxicity. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | neuron-astrocyte co-cultures / N-methyl-D-aspartate(NMDA) receptor / Glu uptake / neuron death |
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| Conference Information | |
| Committee | MBE |
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| Conference Date | 1998/3/19(1days) |
| Place (in Japanese) | (See Japanese page) |
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| Topics (in Japanese) | (See Japanese page) |
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| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Glutamate-induced neurotoxicity in neuron-astrocyte co-cultures from the embryonic rat cortex |
| Sub Title (in English) | |
| Keyword(1) | neuron-astrocyte co-cultures |
| Keyword(2) | N-methyl-D-aspartate(NMDA) receptor |
| Keyword(3) | Glu uptake |
| Keyword(4) | neuron death |
| 1st Author's Name | Junji Hori |
| 1st Author's Affiliation | Research institute for electronic science, Hokkaido University() |
| 2nd Author's Name | Hideomi Sato |
| 2nd Author's Affiliation | Research institute for electronic science, Hokkaido University |
| 3rd Author's Name | Yoshiyasu Kobayashi |
| 3rd Author's Affiliation | School of Medicine, Hokkaido University |
| 4th Author's Name | Kazuo Nagashima |
| 4th Author's Affiliation | School of Medicine, Hokkaido University |
| 5th Author's Name | Yoshiaki Habara |
| 5th Author's Affiliation | Graduate School of Veterinary Medicine, Hokkaido University Lab.of Biomedical Control, Research Institute for Electronic Science, Hokkaido University |
| 6th Author's Name | Koichi Kawahara |
| 6th Author's Affiliation | Research institute for electronic science, Hokkaido University |
| Date | 1998/3/19 |
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| Volume (vol) | vol.97 |
| Number (no) | 621 |
| Page | pp.pp.- |
| #Pages | 6 |
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