| Presentation | 1997/12/12 Transient Behavior and the Optimal Control for Open and Closed states of Calcium Channels Described by an Allosteric Model. H Hirayama, H Sato, T Ito, K Seo, Y Fukuyama, |
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| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Linear system analysis was applied for the molecular interactions of excitation-contraction coupling in skeletal muscle. The contact interaction between the voltage sensor of the transverse tubular membrane of skeletal muscle and the calcium release channel of the sarcoplasmic reticulum was decried by 10 states MWC model. The allosteric protein is the calcium release channel, a homotetramer with two accessible states, closed and open. The kinetics and equilibrium of this transition were modulated by voltage sensors pictured as four units per release channel., each undergoing independent voltage-driven transitions between two states. Linear system analysis revealed that the system was stable and uncontrollable. The impulse responses showed co-operativity among the closed and open states of calcium release channel. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Excitation-contraction / Calcium release channel / MWC model / Voltage sensor / Linear system analysis |
| Paper # | MBE97-122 |
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| Conference Information | |
| Committee | MBE |
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| Conference Date | 1997/12/12(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Chair | |
| Vice Chair | |
| Secretary | |
| Assistant | |
| Paper Information | |
| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | ENG |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Transient Behavior and the Optimal Control for Open and Closed states of Calcium Channels Described by an Allosteric Model. |
| Sub Title (in English) | |
| Keyword(1) | Excitation-contraction |
| Keyword(2) | Calcium release channel |
| Keyword(3) | MWC model |
| Keyword(4) | Voltage sensor |
| Keyword(5) | Linear system analysis |
| 1st Author's Name | H Hirayama |
| 1st Author's Affiliation | The Department of Public Health, Asahikawa Medical College() |
| 2nd Author's Name | H Sato |
| 2nd Author's Affiliation | The Department of Public Health, Asahikawa Medical College |
| 3rd Author's Name | T Ito |
| 3rd Author's Affiliation | The Department of Public Health, Asahikawa Medical College |
| 4th Author's Name | K Seo |
| 4th Author's Affiliation | The Department of Public Health, Asahikawa Medical College |
| 5th Author's Name | Y Fukuyama |
| 5th Author's Affiliation | The Department of Public Health, Asahikawa Medical College |
| Date | 1997/12/12 |
| Paper # | MBE97-122 |
| Volume (vol) | vol.97 |
| Number (no) | 447 |
| Page | pp.pp.- |
| #Pages | 8 |
| Date of Issue | |