Presentation 1997/9/27
On Subjective Effect of Addictive Drug and Temporal Differentiation of Response in Striatum
Yasuhiro SAGAWA,
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Abstract(in Japanese) (See Japanese page)
Abstract(in English) The relationship between subjective effect (euphoria) of cocaine and dopamine transporter (DAT) occupancy in striatum of basal ganglia has been reported. In this research, it is indicated that the subjective effect are thought to correspond to positive temporal differentiation of an amount of dopmaine (DA) (or of neuronal responses) in striatum. And, by assuming that subjective dysphoria corresponds to negative temporal differentiation of the amount of DA (or of neuronal responses) in striatum, an interesting hypothesis concerning a relationship between euphoria and dysphoria is lead theoretically. Furthermore, relationships among subjective feelings (euphoria and dysphoria), DA in striatum, neuronal responses in striatum, neuronal responses in substantia nigra pars compacta (SNc) and ventral tegmental area (VTA), and reinforcement in learning and action selection are discussed.
Keyword(in Japanese) (See Japanese page)
Keyword(in English) addictive drug / subjective effect / striatum / dopamine / temporal differentiation / reinforcement
Paper # MBE97-80
Date of Issue

Conference Information
Committee MBE
Conference Date 1997/9/27(1days)
Place (in Japanese) (See Japanese page)
Place (in English)
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Topics (in English)
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Paper Information
Registration To ME and Bio Cybernetics (MBE)
Language ENG
Title (in Japanese) (See Japanese page)
Sub Title (in Japanese) (See Japanese page)
Title (in English) On Subjective Effect of Addictive Drug and Temporal Differentiation of Response in Striatum
Sub Title (in English)
Keyword(1) addictive drug
Keyword(2) subjective effect
Keyword(3) striatum
Keyword(4) dopamine
Keyword(5) temporal differentiation
Keyword(6) reinforcement
1st Author's Name Yasuhiro SAGAWA
1st Author's Affiliation Department of Biophysical Engineering, Faculty of Engineering Science, Osaka University()
Date 1997/9/27
Paper # MBE97-80
Volume (vol) vol.97
Number (no) 292
Page pp.pp.-
#Pages 7
Date of Issue