Presentation | 2000/12/1 Dopaminergic Effect on Long-term Plasticity in Prefrontal Pyramidal Neuron depending on Dendritic Location of Synaptic Input Kazushi MURAKOSHI, Kiyohiko NAKAMURA, |
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Abstract(in English) | Electrophysiological studies analyzing the effect of dopamine(DA)showed conflicting results; someone reported that DA favored long-term depression(LTD)and the others demonstrated that DA established a robust long-term potentiation(LTP). The question we have to ask here is how these changes in synaptic efficacy is produced by DA. This paper presents analysis on how dopaminergic modulation affects long-term plasticity by computer simulation. The model neuron of this paper is a layer V prefrontal pyramidal neuron consisting of a soma, a basal dendritic, and a proximal and a distal apical dendritic compartment. As a remarkable result, it depended on dendritic location whether LTP or LTD was induced. |
Keyword(in Japanese) | (See Japanese page) |
Keyword(in English) | multicompartment model / action potential / intracellular calcium concentration / receptor phosphorylation |
Paper # | NC2000-81 |
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Committee | NC |
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Conference Date | 2000/12/1(1days) |
Place (in Japanese) | (See Japanese page) |
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Paper Information | |
Registration To | Neurocomputing (NC) |
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Language | JPN |
Title (in Japanese) | (See Japanese page) |
Sub Title (in Japanese) | (See Japanese page) |
Title (in English) | Dopaminergic Effect on Long-term Plasticity in Prefrontal Pyramidal Neuron depending on Dendritic Location of Synaptic Input |
Sub Title (in English) | |
Keyword(1) | multicompartment model |
Keyword(2) | action potential |
Keyword(3) | intracellular calcium concentration |
Keyword(4) | receptor phosphorylation |
1st Author's Name | Kazushi MURAKOSHI |
1st Author's Affiliation | Dept. Computational Intelligence and Systems Science, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology() |
2nd Author's Name | Kiyohiko NAKAMURA |
2nd Author's Affiliation | Dept. Computational Intelligence and Systems Science, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology |
Date | 2000/12/1 |
Paper # | NC2000-81 |
Volume (vol) | vol.100 |
Number (no) | 490 |
Page | pp.pp.- |
#Pages | 8 |
Date of Issue |