| Presentation | 1998/3/19 Time Minimum Optimal Control for Multiple Phase Allosteric Reaction Network Circuit. H Hirayama, Y Okita, Y Fukuyama, |
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| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | We propose the time minimum control principle for multiple phase biochemical reaction circuit and we reported numerical computational results of the temporal changes in the concentrations of the species of the circuit. The reaction circuit was composed of enzyme-substrate-product compound. The enzyme is an allosteric one that transforms after binding substrate or products. This enzyme has two phases, one is a relaxed conformation in which reaction can be activated. Another phase is a tension conformation in which the molecular structure was too strict to access the substrate or the modulator. For these circuit, we set the time optimal control strategy. Total 40 non linear differential equations were solved numerically to show the shortest time course of the species. Changes in the rate limit step has the most potent influence on these time courses. The present method will be available for evaluating the artificial reaction circuit that has biological propertics. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Multiple phase biochemical reaction circuit / time minimum optimal control / enzyme / substrate |
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| Conference Information | |
| Committee | NC |
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| Conference Date | 1998/3/19(1days) |
| Place (in Japanese) | (See Japanese page) |
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| Topics (in Japanese) | (See Japanese page) |
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| Registration To | Neurocomputing (NC) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Time Minimum Optimal Control for Multiple Phase Allosteric Reaction Network Circuit. |
| Sub Title (in English) | |
| Keyword(1) | Multiple phase biochemical reaction circuit |
| Keyword(2) | time minimum optimal control |
| Keyword(3) | enzyme |
| Keyword(4) | substrate |
| 1st Author's Name | H Hirayama |
| 1st Author's Affiliation | Department of Public Health Asahikawa medical college() |
| 2nd Author's Name | Y Okita |
| 2nd Author's Affiliation | Department of Public Health Asahikawa medical college |
| 3rd Author's Name | Y Fukuyama |
| 3rd Author's Affiliation | Department of Public Health Asahikawa medical college |
| Date | 1998/3/19 |
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| Volume (vol) | vol.97 |
| Number (no) | 623 |
| Page | pp.pp.- |
| #Pages | 8 |
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