Presentation 1997/3/7
Transient Responses and Linear System Analysis of Ionic Channels on the Biological Membrane
H. Hirayama, T. Kadota, A. Endoh, A. Kaneko, Y. Fukuyama,
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Abstract(in English) Systemic properties of ionic channels on the biological membrane were investigated by engineering linear system analysis. Calcium ionic channel on the biological membrane was expressed by four idential allosteric units which are voltage sensitive. Five open and closcd states respectively, thus totally 10 states model were expressed by 10 linear state equations with conservation law. Linear system analysis disclosed that these mutual transitional states were stable but uncontrollable. There were six singular values which were relatively insensitive to frequency. The present linear system approach is useful to estimate an integrated properties of transient behaviors of the multiple states ionic channels.
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Keyword(in English) Ion channel / Biological membrane / Gating current / Subunit / Allosteric model / Stability
Paper # EID96-184,OME96-102
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Committee EID
Conference Date 1997/3/7(1days)
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Language JPN
Title (in Japanese) (See Japanese page)
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Title (in English) Transient Responses and Linear System Analysis of Ionic Channels on the Biological Membrane
Sub Title (in English)
Keyword(1) Ion channel
Keyword(2) Biological membrane
Keyword(3) Gating current
Keyword(4) Subunit
Keyword(5) Allosteric model
Keyword(6) Stability
1st Author's Name H. Hirayama
1st Author's Affiliation Department of Public Health Asahikawa medical university()
2nd Author's Name T. Kadota
2nd Author's Affiliation Department of Public Health Asahikawa medical university
3rd Author's Name A. Endoh
3rd Author's Affiliation Department of Public Health Asahikawa medical university
4th Author's Name A. Kaneko
4th Author's Affiliation Department of Public Health Asahikawa medical university
5th Author's Name Y. Fukuyama
5th Author's Affiliation Department of Public Health Asahikawa medical university
Date 1997/3/7
Paper # EID96-184,OME96-102
Volume (vol) vol.96
Number (no) 567
Page pp.pp.-
#Pages 6
Date of Issue