Presentation 1995/7/20
Analysis of Transmission Mechanism of Biochemical Information on a Cellular Level.
H. Hirayama, T. Yamaki, Y. Fukuyama,
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Abstract(in English) A theoretical analysis was performed for the enzymatic molecular mechanism of signal amplification process in the intra cellular signal transduction system. The target system was the cycling reaction system and cascade reaction systems such as Pyruvate and co-enzymes NADH, NAD systems. In both systems, the intermediate products are utilized as substrates for the second step enzyme reactions. When the rate constants of each reaction steps were increased 10 folds, the intermediate products on which the first step and the second step enzyme reactions converge increased for 6000 folds. This shows that signal amplification mechanism in cycling and cascade reaction system must derived in the non linear properties in the reaction system.
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Keyword(in English) Intracellular signal amplification / Cycling reaction / Cascade reaction / Non linearity
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Committee HIP
Conference Date 1995/7/20(1days)
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Language ENG
Title (in Japanese) (See Japanese page)
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Title (in English) Analysis of Transmission Mechanism of Biochemical Information on a Cellular Level.
Sub Title (in English)
Keyword(1) Intracellular signal amplification
Keyword(2) Cycling reaction
Keyword(3) Cascade reaction
Keyword(4) Non linearity
1st Author's Name H. Hirayama
1st Author's Affiliation Department of Public Health Asahikawa Medical College.()
2nd Author's Name T. Yamaki
2nd Author's Affiliation Department of Public Health Asahikawa Medical College.
3rd Author's Name Y. Fukuyama
3rd Author's Affiliation Department of Public Health Asahikawa Medical College.
Date 1995/7/20
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Volume (vol) vol.95
Number (no) 166
Page pp.pp.-
#Pages 6
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