| Presentation | 2004/6/18 Reduction of EPSP Shunting by A-type Potassium Channels and its Effect on Effective Neural Interaction Toru AONISHI, Hiroyoshi MIYAKAWA, Masashi INOUE, Masato OKADA, |
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| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | We elucidate an effect of backpropagating action potentials (BAP) s on neural interaction by the NEURON simulator. If the balance between sensitivities of the inward current channel and the outward current channel is satisfied, there is a singular point where the input impedance of the membrane diverges to ±∞. Such a singular stracture induces the following two discrete states depending on A-channel conductance. If A-channel conductance is lower than a critical value, the shunting inhibition of EPSPs by BAPs ocures in the dendrite. Near a critical value, the polarization of EPSPs is reversed. On the other hand, if A-channel conductance is higher than a critical value, BAPs and EPSPs has weak interaction in the dendrite. Near a critical value, EPSPs are amplified. It has been reported that some neuron modulators can control characteristics of the A-channel. This rises the possibility that some neuron modulators can switch between these two states of the neural interaction. Next, we observe phase response curves of a neuron in oscillatory states. This experiment includes previous experiments for shunting EPSPs, and thus the effect of the shunting of EPSPs on neural interaction can be elucidated. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Dendrite / Backpropagating Action Potential / EPSP / A channel / Na channel / Singular point |
| Paper # | NC2004-30 |
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| Committee | NC |
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| Conference Date | 2004/6/18(1days) |
| Place (in Japanese) | (See Japanese page) |
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| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | Neurocomputing (NC) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Reduction of EPSP Shunting by A-type Potassium Channels and its Effect on Effective Neural Interaction |
| Sub Title (in English) | |
| Keyword(1) | Dendrite |
| Keyword(2) | Backpropagating Action Potential |
| Keyword(3) | EPSP |
| Keyword(4) | A channel |
| Keyword(5) | Na channel |
| Keyword(6) | Singular point |
| 1st Author's Name | Toru AONISHI |
| 1st Author's Affiliation | Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology:Brain Science Institute, RIKEN() |
| 2nd Author's Name | Hiroyoshi MIYAKAWA |
| 2nd Author's Affiliation | Department of Life Science, Tokyo University of Pharmacy and Life Science |
| 3rd Author's Name | Masashi INOUE |
| 3rd Author's Affiliation | Department of Life Science, Tokyo University of Pharmacy and Life Science |
| 4th Author's Name | Masato OKADA |
| 4th Author's Affiliation | Brain Science Institute, RIKEN:"Intelligent Cooperation and Control", PRESTO, JST |
| Date | 2004/6/18 |
| Paper # | NC2004-30 |
| Volume (vol) | vol.104 |
| Number (no) | 140 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |