Presentation | 2004/3/10 The Spatiotemporal Dynamics Theory of Ionic Concentration and Potential Seiichi SAKATANI, Akira HIROSE, |
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Abstract(in Japanese) | (See Japanese page) |
Abstract(in English) | It is well known that membrane potential in neuron is determined by the ionic concentrations and ionic permeability. However, the ionic concentrations are determined by both the ionic flows through the ionic channels and intracellular and extracellular ionic flows. Therefore, it is needed to resolve the intracellular and extracellular ionic concentrations and potential simultaneously. In this paper, we construct the theory for spatiotemporal dynamics of ionic concentration and potential. We adopt Hodgkin-Huxley-type nonlinear conductance to express the ionic permeability and use Nernst-Planck equation to denote the ionic concentrations. Additionally, we have succeeded in constructing the theory by setting the charge conserved at the intracellular fluid, the extracellular one and the boundary. By using the theory, we numerically analyze the distribution of intracellular ionic concentrations and potential. Consequently, the validity of the theory has been confirmed since the results are consistent with those in the physiological experiment. This theory has a high degree of availability since it is extendable to the various types of ionic channels and is applicable to any cells. |
Keyword(in Japanese) | (See Japanese page) |
Keyword(in English) | membrane potential / ionic concentration / Hodgkin-Huxley equation / Nernst-Planck equation / law of conservation of charge |
Paper # | NC2003-136 |
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Committee | NC |
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Conference Date | 2004/3/10(1days) |
Place (in Japanese) | (See Japanese page) |
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Registration To | Neurocomputing (NC) |
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Language | JPN |
Title (in Japanese) | (See Japanese page) |
Sub Title (in Japanese) | (See Japanese page) |
Title (in English) | The Spatiotemporal Dynamics Theory of Ionic Concentration and Potential |
Sub Title (in English) | |
Keyword(1) | membrane potential |
Keyword(2) | ionic concentration |
Keyword(3) | Hodgkin-Huxley equation |
Keyword(4) | Nernst-Planck equation |
Keyword(5) | law of conservation of charge |
1st Author's Name | Seiichi SAKATANI |
1st Author's Affiliation | Department of Frontier Informatics, Graduate School of Frontier Sciences, The University of Tokyo() |
2nd Author's Name | Akira HIROSE |
2nd Author's Affiliation | Department of Frontier Informatics, Graduate School of Frontier Sciences, The University of Tokyo |
Date | 2004/3/10 |
Paper # | NC2003-136 |
Volume (vol) | vol.103 |
Number (no) | 732 |
Page | pp.pp.- |
#Pages | 6 |
Date of Issue |