Presentation 2004/3/10
The relation between Ca^<2+> influx and the magnitude of STDP in the hippocampal neural network
Yasutoshi Kashiwagi, Yoichi Avil, Hidenori Watanabe, Takeshi Aihara, Minoru Tsukada,
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Abstract(in English) In the hippocampal CA1 area, repetitive correlated spiking of pre- and postsynaptic neurons can induce LTP and LTD , depending on the timing of the pre- and postsynaptic excitation(Spike timing Dependent Plasticity). While, it is shown that LTP and LTD are triggered depending on the level of postsynaptic intracellular calcium concentration. In this study , Ca^<2+> influx induced by the protocol of timing between pre- and postsynaptic excitation were spatially investigated by using the calcium imaging method in the hippocampal CA1 area. We analized the dynamics of calcium influx during repetitive stimulus and discussed the relatio between the dynamics and themaghifaile of STDP that the magnitude of LTP and LTD closely related to the velocity of calcium influx during repetitive stimulus.
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Keyword(in English) hippocampus / Ca<2+> / STDP / LTP LTD
Paper # NC2003-135
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Committee NC
Conference Date 2004/3/10(1days)
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Registration To Neurocomputing (NC)
Language JPN
Title (in Japanese) (See Japanese page)
Sub Title (in Japanese) (See Japanese page)
Title (in English) The relation between Ca^<2+> influx and the magnitude of STDP in the hippocampal neural network
Sub Title (in English)
Keyword(1) hippocampus
Keyword(2) Ca<2+>
Keyword(3) STDP
Keyword(4) LTP LTD
1st Author's Name Yasutoshi Kashiwagi
1st Author's Affiliation Tamagawa University()
2nd Author's Name Yoichi Avil
2nd Author's Affiliation Tamagawa University
3rd Author's Name Hidenori Watanabe
3rd Author's Affiliation Tamagawa University
4th Author's Name Takeshi Aihara
4th Author's Affiliation Tamagawa University
5th Author's Name Minoru Tsukada
5th Author's Affiliation Tamagawa University
Date 2004/3/10
Paper # NC2003-135
Volume (vol) vol.103
Number (no) 732
Page pp.pp.-
#Pages 4
Date of Issue