| Presentation | 2003/3/10 Glutamate-induced Intracellular Ca^<2+> oscillation in brain astrocytes Isao GOTO, Kiyohisa NATSUME, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | A kind of the glial cells, astrocyte has glutamate receptors as well as neuronal cells and talks with neurons. In the culture of astrocytes, they have spontaneous [Ca^<2+>]i oscillation and glutamate can induce the several patterns of [Ca^<2+>]i responses. There are four patterns. One of them is a sustained oscillation, another is a dumped oscillation, step rise response and the sustained oscillation, whose frequency gradually decreases. In the present study, we constituted the model which can simulate the glutamate-induced [Ca^<2+>] oscillation and spontaneous [Ca^<2+>]i oscillation observed in the cultured astrocytes using De-Young and Keizer s model. While the model could produce a sustained oscillation, is a dumped oscillation and step rise response, the model could not produce the spontaneous [Ca^<2+>]i oscillation in the astrocytes. Hence, we applied the term of [Ca^<2+>]i activated PLCδ to the model and could produce tbc spontaneous [Ca^<2+>]i oscillation. Therefore, the feed forward process of [IP_3] as the process which PLCδ involves is necessary to have a spontaneous [Ca^<2+>]i oscillation. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | astrocyte / [Ca2+]i oscillation / PLCδ / De-Young & Keizer's model / glutamate |
| Paper # | NC2002-136 |
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| Committee | NC |
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| Conference Date | 2003/3/10(1days) |
| Place (in Japanese) | (See Japanese page) |
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| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | Neurocomputing (NC) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Glutamate-induced Intracellular Ca^<2+> oscillation in brain astrocytes |
| Sub Title (in English) | |
| Keyword(1) | astrocyte |
| Keyword(2) | [Ca2+]i oscillation |
| Keyword(3) | PLCδ |
| Keyword(4) | De-Young & Keizer's model |
| Keyword(5) | glutamate |
| 1st Author's Name | Isao GOTO |
| 1st Author's Affiliation | Grad Sch Life Sci and Sci Eng, Kyushu Inst Tech() |
| 2nd Author's Name | Kiyohisa NATSUME |
| 2nd Author's Affiliation | Grad Sch Life Sci and Sci Eng, Kyushu Inst Tech |
| Date | 2003/3/10 |
| Paper # | NC2002-136 |
| Volume (vol) | vol.102 |
| Number (no) | 729 |
| Page | pp.pp.- |
| #Pages | 6 |
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