Presentation 2002/12/6
A Model of Transmitter Release in the Synaptic Terminals of Retinal Bipolar Cells
Tomokatsu KAWAKITA, Akito ISHIHARA, Shiro USUI, Masao TACHIBANA,
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Abstract(in English) Retinal bipolar cells, which show a graded response to light stimulation, release glutamate as the transmitter phasically and tonically, and transmit the visual signal continuously to postsynaptic neurons. We constructed a mathematical model of glutamate release from bipolar cells by integrating the various physiological data. This model could simulate the voltage- and calcium-dependence of glutamate release. A simulation experiment revealed that the slow component of glutamate release was delayed by introduction of exogenous calcium buffer into the cell. This result suggests that the slow component contributes to the bell-shaped relationship between glutamate release and membrane potential.
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Keyword(in English) Mathematical Model / Retinal Bipolar Cell / Synaptic Terminal / Transmitter Release
Paper # NC2002-93
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Committee NC
Conference Date 2002/12/6(1days)
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Registration To Neurocomputing (NC)
Language JPN
Title (in Japanese) (See Japanese page)
Sub Title (in Japanese) (See Japanese page)
Title (in English) A Model of Transmitter Release in the Synaptic Terminals of Retinal Bipolar Cells
Sub Title (in English)
Keyword(1) Mathematical Model
Keyword(2) Retinal Bipolar Cell
Keyword(3) Synaptic Terminal
Keyword(4) Transmitter Release
1st Author's Name Tomokatsu KAWAKITA
1st Author's Affiliation Department of Information & Computer Sciences, Toyohashi University of Technology()
2nd Author's Name Akito ISHIHARA
2nd Author's Affiliation Department of Information & Computer Sciences, Toyohashi University of Technology
3rd Author's Name Shiro USUI
3rd Author's Affiliation Department of Information & Computer Sciences, Toyohashi University of Technology
4th Author's Name Masao TACHIBANA
4th Author's Affiliation Department of Psychology, Graduate School of Humanities & Sociology, University of Tokyo
Date 2002/12/6
Paper # NC2002-93
Volume (vol) vol.102
Number (no) 508
Page pp.pp.-
#Pages 6
Date of Issue