| Presentation | 2002/6/21 Kinetic Simulation of Signal Transduction to Convert Timing of Inputs to Ca^2+ Concentration in Cerebellar Purkinje Cells Tomokazu DOI, Shinya KURODA, Takayuki MICHIKAWA, Mitsuo KAWATO, |
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| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Cerebellar long-term depression(LTD) is induced by conjunctive inputs of parallel and climbing fiber. When parallel fiber inputs proceed to climbing fiber input, ca^2+ concentration at the spine in the Purkinje cell dramatically increases and LTD occurs. However, molecular dynamics of coincidence detection is unclear. We developed a quantitive model of signal transdution and analyzed the dynamics to convert input timing to Ca^2+ concentration. We found that increase in ca^2+ concentration is a threshold phenomenon. The larger inositol-1,4,5-triphosphate(IP_3) concentration increases via parallel fiber inputs, the lower the threshold becomes. Experiments for cerebellar LTD with various conditions can be interpreted as different aspects of the same mechanism. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Signal Transduction / Time Window / Ca^2+ / IP_3 / Threshold |
| Paper # | NC2002-21 |
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| Committee | NC |
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| Conference Date | 2002/6/21(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | Neurocomputing (NC) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Kinetic Simulation of Signal Transduction to Convert Timing of Inputs to Ca^2+ Concentration in Cerebellar Purkinje Cells |
| Sub Title (in English) | |
| Keyword(1) | Signal Transduction |
| Keyword(2) | Time Window |
| Keyword(3) | Ca^2+ |
| Keyword(4) | IP_3 |
| Keyword(5) | Threshold |
| 1st Author's Name | Tomokazu DOI |
| 1st Author's Affiliation | Graduate School of Information Science, Nara Institute of Science and Technology:ATR Human Information Science Laboratories() |
| 2nd Author's Name | Shinya KURODA |
| 2nd Author's Affiliation | Graduate School of Information Science and Technology, The University of Tokyo |
| 3rd Author's Name | Takayuki MICHIKAWA |
| 3rd Author's Affiliation | The institute of Medical Science, The University of Tokyo |
| 4th Author's Name | Mitsuo KAWATO |
| 4th Author's Affiliation | ATR Human Information Science Laboratories:Graduate School of Information Science, Nara Institute of Science and Technology |
| Date | 2002/6/21 |
| Paper # | NC2002-21 |
| Volume (vol) | vol.102 |
| Number (no) | 158 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |