| Presentation | 2003/12/11 The Effect of Intra-cellular Calcium Stores on The Insulin Secretion of a Pancreatic β-Cells Cluster Shinya MIYAMOTO, Shinji DOI, Sadatoshi KUMAGAI, |
|---|---|
| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | In response to glucose, pancreatic β-cells in the islets of Langerhans secrete insulin. On the other hand, the membrane potential of β-cell shows characteristic wave form known as bursting. It is considered that insulin secretion is greatly related to the bursting of pancreatic β-cell. We study two kinds of Hodgkin-Huxley type models with or without intra-cellular calcium stores which show the same bursting in the single cells but have different features between them in the cluster of coupled cells. We analize the effect of intra-cellular calcium stores on the entire bursting (insulin secretion). Especially, we clarify the mechanism of the bursting in terms of singularly perturbed systems. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | pancreatic βcell / bursting / slow-fast analysis / bifurcation structure |
| Paper # | NLP2003-136 |
| Date of Issue |
| Conference Information | |
| Committee | NLP |
|---|---|
| Conference Date | 2003/12/11(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Chair | |
| Vice Chair | |
| Secretary | |
| Assistant | |
| Paper Information | |
| Registration To | Nonlinear Problems (NLP) |
|---|---|
| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | The Effect of Intra-cellular Calcium Stores on The Insulin Secretion of a Pancreatic β-Cells Cluster |
| Sub Title (in English) | |
| Keyword(1) | pancreatic βcell |
| Keyword(2) | bursting |
| Keyword(3) | slow-fast analysis |
| Keyword(4) | bifurcation structure |
| 1st Author's Name | Shinya MIYAMOTO |
| 1st Author's Affiliation | Department of Electrical Engineering, Graduate School of Engineering, Osaka University() |
| 2nd Author's Name | Shinji DOI |
| 2nd Author's Affiliation | Department of Electrical Engineering, Graduate School of Engineering, Osaka University |
| 3rd Author's Name | Sadatoshi KUMAGAI |
| 3rd Author's Affiliation | Department of Electrical Engineering, Graduate School of Engineering, Osaka University |
| Date | 2003/12/11 |
| Paper # | NLP2003-136 |
| Volume (vol) | vol.103 |
| Number (no) | 503 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |