| Presentation | 2003/10/17 Functional Characterization of Squid Voltage-dependent Calcium Channel : Comparative Physiological and Biochemical Study Tadashi Kimura, |
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| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Squid voltage-dependent calcium channel α1 (LoCa_v2) and β subunits (LoCa_vβ1a and LoCa_vβ1b) were cloned from the optic lobe. Functional expression and pharmacological experiments revealed that the LoCa_v2 current was high voltage-activated and lasted for long during activation. The LoCa_v2 current was inhibited by PLTX-II. LoCa_vβ1a-induced current amplitude was about 2-4 times higher than that of LoCa_β1b. Experiments with point mutants and chimeras suggest that potential PKC and CK2 phosphorylation sites in the N-terminal region of LoCa_vβ1b affect the current amplitude reciprocally, and may be responsible for regulating current amplitude. Two models of the regulating mechanism are proposed. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Squid / Voltage dependent calcium channel / pharmacology / current control / phosphorylation |
| Paper # | OME2003-94 |
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| Conference Information | |
| Committee | OME |
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| Conference Date | 2003/10/17(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | Organic Material Electronics (OME) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Functional Characterization of Squid Voltage-dependent Calcium Channel : Comparative Physiological and Biochemical Study |
| Sub Title (in English) | |
| Keyword(1) | Squid |
| Keyword(2) | Voltage dependent calcium channel |
| Keyword(3) | pharmacology |
| Keyword(4) | current control |
| Keyword(5) | phosphorylation |
| 1st Author's Name | Tadashi Kimura |
| 1st Author's Affiliation | Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology (AIST),() |
| Date | 2003/10/17 |
| Paper # | OME2003-94 |
| Volume (vol) | vol.103 |
| Number (no) | 393 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |