| Presentation | 2004/3/11 An in vitro Study of Cholonergic Modulation in the Rat Striatum Takayuki KUSHIMA, Wen-jie SONG, |
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| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | This study aims to elucidate actions of acetylcholine on corticostriatal synaptic transmission and the membrane excitability of striatal cholinergic interneurons. Whole-cell recordings were obtained from cholinergic interneurons in slice preparations of rats (postnatal day 14-23). Stimulation of the subcortical white matter evoked excitatory postsynaptic potentials (EPSPs) in cholinergic interneurons. Bath application of a muscarinic recepter agonist caused a slow depolarization and reduced the EPSP amplitude. This depolarization was antagonized by tetrodotoxin, a selective blocker of Na^+ channels. These data suggest that acetylcholine in the striatum promotes the membrane excitability of cholinergic interneurons indirectly and inhibits inputs from cortex to cholinergic interneurons. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | striatum / cholinergic interneurons / acetylcholine / whole-cell recording / excitatory postsynaptic potential |
| Paper # | MBE2003-158 |
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| Conference Information | |
| Committee | MBE |
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| Conference Date | 2004/3/11(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Chair | |
| Vice Chair | |
| Secretary | |
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| Paper Information | |
| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | An in vitro Study of Cholonergic Modulation in the Rat Striatum |
| Sub Title (in English) | |
| Keyword(1) | striatum |
| Keyword(2) | cholinergic interneurons |
| Keyword(3) | acetylcholine |
| Keyword(4) | whole-cell recording |
| Keyword(5) | excitatory postsynaptic potential |
| 1st Author's Name | Takayuki KUSHIMA |
| 1st Author's Affiliation | Graduate School of Engineering, Osaka University() |
| 2nd Author's Name | Wen-jie SONG |
| 2nd Author's Affiliation | Graduate School of Engineering, Osaka University |
| Date | 2004/3/11 |
| Paper # | MBE2003-158 |
| Volume (vol) | vol.103 |
| Number (no) | 731 |
| Page | pp.pp.- |
| #Pages | 5 |
| Date of Issue | |