| Presentation | 2004/3/11 Computational study on the regulation of Ca^<2+> concentration at the presynaptic terminal of the retinal bipolar cell Yoshimitsu KIMURA, Makoto OSANAI, Tetsuya YAGI, |
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| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | The retinal bipolar cells respond to the light stimuli with a graded potential change. The bipolar cells have a center-surround receptive field. They exhibit the membrane potential changes toward both the directions of depolarization and hyperpolarization. In order to transmit these responses to the ganglion cells, the intracellular Ca^<2+> concentration at the axon terminal region ([Ca^<2+>]_i) must be relatively high in the dark condition and need to increase or to decrease depends on the light stimulus. We conducted a computer simulation analysis using the biophysical models of the cell morphology, the ion channels and the Ca^<2+>-regulation machineries. When L-type Ca^<2+> channel was locally distributed at the tip of the terminal region, which may correspond to the Ca^<2+>-domain region, and Ca^<2+>-ATPase was concentrated at the terminal region exclusive of the Ca^<2+>-domain, the[Ca^<2+>]_i changed suitably for the transmission of the light stimulus information. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Retina / Bipolar cell / Calcium / Computer Simulation / Transmitter Release |
| Paper # | MBE2003-156 |
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| Conference Information | |
| Committee | MBE |
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| Conference Date | 2004/3/11(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Computational study on the regulation of Ca^<2+> concentration at the presynaptic terminal of the retinal bipolar cell |
| Sub Title (in English) | |
| Keyword(1) | Retina |
| Keyword(2) | Bipolar cell |
| Keyword(3) | Calcium |
| Keyword(4) | Computer Simulation |
| Keyword(5) | Transmitter Release |
| 1st Author's Name | Yoshimitsu KIMURA |
| 1st Author's Affiliation | Graduate School of Engineering, Osaka University() |
| 2nd Author's Name | Makoto OSANAI |
| 2nd Author's Affiliation | Graduate School of Engineering, Osaka University |
| 3rd Author's Name | Tetsuya YAGI |
| 3rd Author's Affiliation | Graduate School of Engineering, Osaka University |
| Date | 2004/3/11 |
| Paper # | MBE2003-156 |
| Volume (vol) | vol.103 |
| Number (no) | 731 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |