| Presentation | 2004/3/10 Regulation of cell metabolism of cardiac myocytes by enhanced production of nitric oxide during ischemia Takahiro YOKOKAWA, oichi KAWAHARA, Takayuki NAKAJIMA, Yoshiko YAMAUCHI, Takeru NAIKI, |
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| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Our previous study has suggested that nitric oxide (NO) produced during ischemia is involved in the protection of cultured cardiac myocytes from ischemia/reperfusion-induced cell death. In this study, we have tried to clarify whether and how NO is involved in the strategy for survival of cardiac myocytes against ischemic stress by assessing the metabolic status of myocytes during ischemia and cell death. The present findings suggested that the increased production of NO by the activation of nitric oxide synthase (NOS), especially of nNOS, played an important role in preserving intracellular ATP during ischemia as well as in protecting cardiac myocytes from ischemia/reperfusion-induced cell death. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | ischemia / reperfusion / nitric oxide (NO) / cardiac myocytes / ATP / nitric oxide synthase (NOS) |
| Paper # | MBE2003-129 |
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| Conference Information | |
| Committee | MBE |
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| Conference Date | 2004/3/10(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Chair | |
| Vice Chair | |
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| Paper Information | |
| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Regulation of cell metabolism of cardiac myocytes by enhanced production of nitric oxide during ischemia |
| Sub Title (in English) | |
| Keyword(1) | ischemia |
| Keyword(2) | reperfusion |
| Keyword(3) | nitric oxide (NO) |
| Keyword(4) | cardiac myocytes |
| Keyword(5) | ATP |
| Keyword(6) | nitric oxide synthase (NOS) |
| 1st Author's Name | Takahiro YOKOKAWA |
| 1st Author's Affiliation | Research Institute for Electronic Science, Hokkaido University() |
| 2nd Author's Name | oichi KAWAHARA |
| 2nd Author's Affiliation | Research Institute for Electronic Science, Hokkaido University |
| 3rd Author's Name | Takayuki NAKAJIMA |
| 3rd Author's Affiliation | Research Institute for Electronic Science, Hokkaido University |
| 4th Author's Name | Yoshiko YAMAUCHI |
| 4th Author's Affiliation | Research Institute for Electronic Science, Hokkaido University |
| 5th Author's Name | Takeru NAIKI |
| 5th Author's Affiliation | Research Institute for Electronic Science, Hokkaido University |
| Date | 2004/3/10 |
| Paper # | MBE2003-129 |
| Volume (vol) | vol.103 |
| Number (no) | 730 |
| Page | pp.pp.- |
| #Pages | 5 |
| Date of Issue | |