| Presentation | 2003/7/5 Visualization of Coronary Microcirculation in Rats and Analysis of Size-dependent Flow Control Masanori HIROTA, Yousuke INAI, Takahiko KIYOOKA, Hitoshi MINAMI, Taro MORIMOTO, Yuki MORIZANE, Tatsuo IWASAKI, Jin Hua BAO, Satoshi MOHRI, Juichiro SHIMIZU, Yasuo OGASAWARA, Shunji SANO, Fumihiko KAJIYA, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Background: Nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF) size-dependently modulate vascular tone of coronary artery. We visualized in vivo both arterial and venous microcirculation in rats to examine whether hierarchical flow regulation of coronary vein depended on NO and EDHF. Methods: Subepicardial microvessels were observed by intravital videomicroscope under cyclooxygenase blockade. Coronary vascular responses to acetylcholine (ACh) were examined under two conditions; ACh and ACh + NO synthase inhibitor. We classified microvessels in terms of their diameters; arterioles & venules (<100μm), and small arteries & veins (>1OO μm). Results: Both arterioles and venules were dilated by ACh more than small arteries and veins, respectively, with greater dilation in arterial system. Small veins changed little after each intervention, while small arteries exhibited significant dilation. Both arterioles and small arteries were suppressed by NO synthase inhibitor, with greater residual dilation in arterioles. In venules, vasodilation was suppressed by NO synthase inhibitor like arterial side. Small veins did not response to NO synthase inhibitor. Conclusions: Coronary arterial and venous microvessels were hierarchically modulated by both NO and EDHF without any vascular response to these substance in small veins. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | hierarchical coronary flow control / coronary microcirculation / nitric oxide / endothelium-derived / hyperpolarizing factor / intravital microscope / rat |
| Paper # | MBE2003-27 |
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| Conference Information | |
| Committee | MBE |
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| Conference Date | 2003/7/5(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | ENG |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Visualization of Coronary Microcirculation in Rats and Analysis of Size-dependent Flow Control |
| Sub Title (in English) | |
| Keyword(1) | hierarchical coronary flow control |
| Keyword(2) | coronary microcirculation |
| Keyword(3) | nitric oxide |
| Keyword(4) | endothelium-derived |
| Keyword(5) | hyperpolarizing factor |
| Keyword(6) | intravital microscope |
| Keyword(7) | rat |
| 1st Author's Name | Masanori HIROTA |
| 1st Author's Affiliation | Departments of Cardiovascular Surgery, Okayama University Graduate School of Medicine and Dentistry:Departments of Cardiovascular Physiology, Okayama University Graduate School of Medicine and Dentistry() |
| 2nd Author's Name | Yousuke INAI |
| 2nd Author's Affiliation | Departments of Cardiovascular Physiology, Okayama University Graduate School of Medicine and Dentistry |
| 3rd Author's Name | Takahiko KIYOOKA |
| 3rd Author's Affiliation | Departments of Cardiovascular Physiology, Okayama University Graduate School of Medicine and Dentistry |
| 4th Author's Name | Hitoshi MINAMI |
| 4th Author's Affiliation | Departments of Cardiovascular Physiology, Okayama University Graduate School of Medicine and Dentistry |
| 5th Author's Name | Taro MORIMOTO |
| 5th Author's Affiliation | Departments of Cardiovascular Physiology, Okayama University Graduate School of Medicine and Dentistry |
| 6th Author's Name | Yuki MORIZANE |
| 6th Author's Affiliation | Departments of Cardiovascular Physiology, Okayama University Graduate School of Medicine and Dentistry |
| 7th Author's Name | Tatsuo IWASAKI |
| 7th Author's Affiliation | Departments of Cardiovascular Physiology, Okayama University Graduate School of Medicine and Dentistry |
| 8th Author's Name | Jin Hua BAO |
| 8th Author's Affiliation | Departments of Cardiovascular Physiology, Okayama University Graduate School of Medicine and Dentistry |
| 9th Author's Name | Satoshi MOHRI |
| 9th Author's Affiliation | Departments of Cardiovascular Physiology, Okayama University Graduate School of Medicine and Dentistry |
| 10th Author's Name | Juichiro SHIMIZU |
| 10th Author's Affiliation | Departments of Cardiovascular Physiology, Okayama University Graduate School of Medicine and Dentistry |
| 11th Author's Name | Yasuo OGASAWARA |
| 11th Author's Affiliation | Department of Medical Engineering and Systems Cardiology, Kawasaki Medical School |
| 12th Author's Name | Shunji SANO |
| 12th Author's Affiliation | Departments of Cardiovascular Surgery, Okayama University Graduate School of Medicine and Dentistry |
| 13th Author's Name | Fumihiko KAJIYA |
| 13th Author's Affiliation | Departments of Cardiovascular Physiology, Okayama University Graduate School of Medicine and Dentistry |
| Date | 2003/7/5 |
| Paper # | MBE2003-27 |
| Volume (vol) | vol.103 |
| Number (no) | 183 |
| Page | pp.pp.- |
| #Pages | 4 |
| Date of Issue | |