| Presentation | 2017-11-24 Extracellular diffusion analysis in the mouse cortex using in vivo integrative optical imaging method Yui Hiroya, Kenya Tanaka, Yuto Yoshida, Akihiro Karashima, Mitsuyuki Nakao, Norihiro Katayama, |
|---|---|
| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | The brain has an unique waste clearance system, called glymphatic system, which is activated during sleep state. In order to know the mechanism of the state-dependency of the system, various methods were applied to measure diffusion property of brain parenchyma. However, the mechanism is still unknown due to the low time resolution of those methods. In this study, by using repetitive integrative optical imaging method, we measured the diffusion property of brain parenchyma in the primary somatosensory cortex of a mouse under the isoflurane anesthetized condition. As a result, we found that there is a drift of diffusion in brain parenchyma. In addition, we found weak correlation between variance of EEG and diffusion coefficient. These results suggest that directed cerebrospinal fluid flows in the brain and the diffusion property changes depending on the concentration of anesthesia. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Glymphatic system / Extracellular space / Integrative Optical Imaging |
| Paper # | MBE2017-47 |
| Date of Issue | 2017-11-17 (MBE) |
| Conference Information | |
| Committee | MBE / NC |
|---|---|
| Conference Date | 2017/11/24(2days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Tohoku University |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | BCI/BMI, generall |
| Chair | Kazuki Nakajima(Univ. of Toyama) / Masafumi Hagiwara(Keio Univ.) |
| Vice Chair | Masaki Kyoso(TCU) / Yutaka Hirata(Chubu Univ.) |
| Secretary | Masaki Kyoso(Toyama Pref. Univ.) / Yutaka Hirata(Kindai Univ.) |
| Assistant | Kim Juhyon(Univ. of Toyama) / Takumi Kobayashi(YNU) / Yoshihisa Shinozawa(Keio Univ.) / Keiichiro Inagaki(Chubu Univ.) |
| Paper Information | |
| Registration To | Technical Committee on ME and Bio Cybernetics / Technical Committee on Neurocomputing |
|---|---|
| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Extracellular diffusion analysis in the mouse cortex using in vivo integrative optical imaging method |
| Sub Title (in English) | |
| Keyword(1) | Glymphatic system |
| Keyword(2) | Extracellular space |
| Keyword(3) | Integrative Optical Imaging |
| 1st Author's Name | Yui Hiroya |
| 1st Author's Affiliation | Tohoku University(Tohoku Univ.) |
| 2nd Author's Name | Kenya Tanaka |
| 2nd Author's Affiliation | Tohoku University(Tohoku Univ.) |
| 3rd Author's Name | Yuto Yoshida |
| 3rd Author's Affiliation | Tohoku University(Tohoku Univ.) |
| 4th Author's Name | Akihiro Karashima |
| 4th Author's Affiliation | Tohoku Institute of Technology(TOHTECH) |
| 5th Author's Name | Mitsuyuki Nakao |
| 5th Author's Affiliation | Tohoku University(Tohoku Univ.) |
| 6th Author's Name | Norihiro Katayama |
| 6th Author's Affiliation | Tohoku University(Tohoku Univ.) |
| Date | 2017-11-24 |
| Paper # | MBE2017-47 |
| Volume (vol) | vol.117 |
| Number (no) | MBE-324 |
| Page | pp.pp.5-8(MBE), |
| #Pages | 4 |
| Date of Issue | 2017-11-17 (MBE) |