| Presentation | 2017-11-09 On the effect of noise on a mathematical model of the pancreatic beta cell Tomoyoshi Kojo, Hiroyasu Ando, Kantaro Fujiwara, Masashi Yoshida, Masafumi Kakei, |
|---|---|
| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | The membrane potential of pancreatic beta cells changes its value in accordance with insulin secretion. In normal beta cells, the change of membrane potential shows periodic bursting, while the bursting of cells in diabetes patients is not periodic, namely the insulin secretion is disordered. In this study, the dynamics of the membrane potential is reproduced by numerical simulation of a mathematical model, and the effect of noise on the model is investigated. As a result of the simulation, we confirm that the number of spikes which corresponds to insulin secretion increases due to noise. We also confirm that the stronger the noise amplitude is, the more the number of spikes increases. Furthermore, the number of spikes more increases for the parameters of the model in which the bursting is not periodic than for that of periodic bursting. This result implies that noise stimulation can promote the amount of insulin secretion for the disordered beta cell compared with the normal cell. Thus, the noisy stimulation would be useful for the remedy for diabetes. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Pancreatic beta cell,Insulin secretionBurstingNoise |
| Paper # | CCS2017-25 |
| Date of Issue | 2017-11-02 (CCS) |
| Conference Information | |
| Committee | CCS |
|---|---|
| Conference Date | 2017/11/9(2days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Osaka Univ. |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Chair | Naoki Wakamiya(Osaka Univ.) |
| Vice Chair | Mikio Hasegawa(Tokyo Univ. of Science) / Makoto Naruse(NICT) |
| Secretary | Mikio Hasegawa(Osaka Univ.) / Makoto Naruse(Tokyo City Univ.) |
| Assistant | Chisa Takano(Hirishima City Univ.) / Takashi Shimada(Univ. of Tokyo) / Tomoya Suzuki(Ibaraki Univ.) / Ryo Takahashi(AUT) |
| Paper Information | |
| Registration To | Technical Committee on Complex Communication Sciences |
|---|---|
| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | On the effect of noise on a mathematical model of the pancreatic beta cell |
| Sub Title (in English) | |
| Keyword(1) | Pancreatic beta cell,Insulin secretionBurstingNoise |
| 1st Author's Name | Tomoyoshi Kojo |
| 1st Author's Affiliation | University of Tsukuba(Univ. of Tsukuba) |
| 2nd Author's Name | Hiroyasu Ando |
| 2nd Author's Affiliation | University of Tsukuba(Univ. of Tsukuba) |
| 3rd Author's Name | Kantaro Fujiwara |
| 3rd Author's Affiliation | Tokyo University of Science(Tokyo Univ. of Sci.) |
| 4th Author's Name | Masashi Yoshida |
| 4th Author's Affiliation | Jichi Medical University Saitama Medical Center(Jichi Med. Univ.) |
| 5th Author's Name | Masafumi Kakei |
| 5th Author's Affiliation | Jichi Medical University Saitama Medical Center(Jichi Med. Univ.) |
| Date | 2017-11-09 |
| Paper # | CCS2017-25 |
| Volume (vol) | vol.117 |
| Number (no) | CCS-288 |
| Page | pp.pp.25-28(CCS), |
| #Pages | 4 |
| Date of Issue | 2017-11-02 (CCS) |