| Presentation | 2017-11-25 Basic study of animal test alternative using cultured nerve cell for the safety assessment of neural interface Yurina Yoshimura, Hiroyuki Tashiro, Yuzo Kayamori, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Direct neural interface is intensively developed to artificially reproduce a lost sensation. The safety of it is evaluated by animal experiment. However, the evaluation using experimental animal has not only problems of high economic and temporal cost but also ethical issues. Therefore, we are developing an animal test alternative that can evaluate the influence of stimulation to nerve cells in vitro. In this study, we investigated the period during which neural activity of nerve cells (NG108?15) cultured on multi electrode array is maintained. Using culture method with medium circulation, the spontaneous-spike activity was able to be obtained until 62.5 hours. Furthermore, the record of nerve activity over 9 days was achieved by culture method with medium exchanging. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Multi electrode array / NG108-15 cells / Spontaneous spike activity / Direct neural interface / Animal test alternative |
| Paper # | MBE2017-49 |
| Date of Issue | 2017-11-17 (MBE) |
| Conference Information | |
| Committee | MBE / NC |
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| Conference Date | 2017/11/24(2days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Tohoku University |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | BCI/BMI, generall |
| Chair | Kazuki Nakajima(Univ. of Toyama) / Masafumi Hagiwara(Keio Univ.) |
| Vice Chair | Masaki Kyoso(TCU) / Yutaka Hirata(Chubu Univ.) |
| Secretary | Masaki Kyoso(Toyama Pref. Univ.) / Yutaka Hirata(Kindai Univ.) |
| Assistant | Kim Juhyon(Univ. of Toyama) / Takumi Kobayashi(YNU) / Yoshihisa Shinozawa(Keio Univ.) / Keiichiro Inagaki(Chubu Univ.) |
| Paper Information | |
| Registration To | Technical Committee on ME and Bio Cybernetics / Technical Committee on Neurocomputing |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Basic study of animal test alternative using cultured nerve cell for the safety assessment of neural interface |
| Sub Title (in English) | |
| Keyword(1) | Multi electrode array |
| Keyword(2) | NG108-15 cells |
| Keyword(3) | Spontaneous spike activity |
| Keyword(4) | Direct neural interface |
| Keyword(5) | Animal test alternative |
| 1st Author's Name | Yurina Yoshimura |
| 1st Author's Affiliation | Kyushu University(kyushu Univ.) |
| 2nd Author's Name | Hiroyuki Tashiro |
| 2nd Author's Affiliation | Kyushu University(kyushu Univ.) |
| 3rd Author's Name | Yuzo Kayamori |
| 3rd Author's Affiliation | Kyushu University(kyushu Univ.) |
| Date | 2017-11-25 |
| Paper # | MBE2017-49 |
| Volume (vol) | vol.117 |
| Number (no) | MBE-324 |
| Page | pp.pp.13-16(MBE), |
| #Pages | 4 |
| Date of Issue | 2017-11-17 (MBE) |