| Presentation | 2016-05-20 The Detection of the Spatial Distribution of Small-molecule Drugs via Phase-sensitive Coherent Raman Microspectroscopy Yuki Obara, Terumasa Ito, Kazuhiko Misawa, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Two- or three-dimensional imaging of molecular species is quite important for life science research. Most drugs are small molecules ; however, these molecules are difficult to detect in biological materials because they cannot be labeled with chromophores. In this study, we demonstrated two dimensional imaging using intrinsic molecular vibrations. We developed novel phase-modulation in heterodyne-detected multiplex coherent Raman spectroscopy called quadrature-phase modulation and improved its spectral acquisition time. We successfully constructed a series of sliced two-dimensional images from vibrational Raman spectra. As a quasi-biomedical sample, droplets of small molecule drugs in an aqueous environment were employed. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Coherent Raman / Phase modulation |
| Paper # | LQE2016-12 |
| Date of Issue | 2016-05-12 (LQE) |
| Conference Information | |
| Committee | LQE / LSJ |
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| Conference Date | 2016/5/19(2days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Chair | Susumu Noda(Kyoto Univ.) |
| Vice Chair | Tsuyoshi Yamamoto(Fujitsu Labs.) |
| Secretary | Tsuyoshi Yamamoto(NTT) / (Tohoku Univ.) |
| Assistant | |
| Paper Information | |
| Registration To | Technical Committee on Lasers and Quantum Electronics / The Laser Society of Japan |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | The Detection of the Spatial Distribution of Small-molecule Drugs via Phase-sensitive Coherent Raman Microspectroscopy |
| Sub Title (in English) | |
| Keyword(1) | Coherent Raman |
| Keyword(2) | Phase modulation |
| 1st Author's Name | Yuki Obara |
| 1st Author's Affiliation | Tokyo University of Agriculture and Technology(TUAT) |
| 2nd Author's Name | Terumasa Ito |
| 2nd Author's Affiliation | Tokyo University of Agriculture and Technology(TUAT) |
| 3rd Author's Name | Kazuhiko Misawa |
| 3rd Author's Affiliation | Tokyo University of Agriculture and Technology(TUAT) |
| Date | 2016-05-20 |
| Paper # | LQE2016-12 |
| Volume (vol) | vol.116 |
| Number (no) | LQE-52 |
| Page | pp.pp.55-58(LQE), |
| #Pages | 4 |
| Date of Issue | 2016-05-12 (LQE) |