| 講演名 | 2016-03-03 A Colored Hybrid Petri Net Model for the Delta-Notch Dependent Boundary Formation in the Drosophila Large Intestine Fei Liu(山口大), Hiroshi Matsuno(山口大), Ryutaro Murakami(山口大), |
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| 抄録(和) | The modeling of the boundary formation in the Drosophila large intestine is a typical mutiscale problem, and it is either time-consuming or hardly addressed by common modeling and simulation tools. As a powerful multiscale modeling and analysis tool for large-scale biological systems, colored hybrid Petri nets can be used to cope with such system. In this paper, we apply colored hybrid Petri nets to model the boundary formation in the large intestine of Drosophila embryo, and build a colored hybrid Petri net model for this biological phenomenon. We validate the model in the wild-type conditions and use the model to make predictions in different over-expression rates of Notch proteins, which well match the experimental observations in vivo. We have shown that colored Petri nets are very appropriate to model such multicellular systems, and our model is scalable and thus we can easily study the model behavior on different size of intestinal tissues. |
| 抄録(英) | The modeling of the boundary formation in the Drosophila large intestine is a typical mutiscale problem, and it is either time-consuming or hardly addressed by common modeling and simulation tools. As a powerful multiscale modeling and analysis tool for large-scale biological systems, colored hybrid Petri nets can be used to cope with such system. In this paper, we apply colored hybrid Petri nets to model the boundary formation in the large intestine of Drosophila embryo, and build a colored hybrid Petri net model for this biological phenomenon. We validate the model in the wild-type conditions and use the model to make predictions in different over-expression rates of Notch proteins, which well match the experimental observations in vivo. We have shown that colored Petri nets are very appropriate to model such multicellular systems, and our model is scalable and thus we can easily study the model behavior on different size of intestinal tissues. |
| キーワード(和) | colored hybrid Petri nets / Delta-Notch signaling pathway / boundary formation / Drosophila large intestine |
| キーワード(英) | colored hybrid Petri nets / Delta-Notch signaling pathway / boundary formation / Drosophila large intestine |
| 資料番号 | MSS2015-76 |
| 発行日 | 2016-02-25 (MSS) |
| 研究会情報 | |
| 研究会 | MSS |
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| 開催期間 | 2016/3/3(から2日開催) |
| 開催地（和） | 海峡メッセ下関 |
| 開催地（英） | KAIKYO MESSE SHIMONOSEKI |
| テーマ（和） | 離散事象システム及び一般、Work In Progress、計測と自動制御学会・離散事象システム部会と併催 |
| テーマ（英） | |
| 委員長氏名（和） | 山根 智(金沢大) |
| 委員長氏名（英） | Satoshi Yamane(Kanazawa Univ.) |
| 副委員長氏名（和） | 名嘉村 盛和(琉球大) |
| 副委員長氏名（英） | Morikazu Nakamura(Univ. of Ryukyus) |
| 幹事氏名（和） | 中田 充(山口大) / 豊嶋 伊知郎(東芝) |
| 幹事氏名（英） | Mitsuru Nakata(Yamaguchi Univ.) / Ichiro Toyoshima(Toshiba) |
| 幹事補佐氏名（和） | 金城 秀樹(沖縄大) |
| 幹事補佐氏名（英） | Hideki Kinjo(Okinawa Univ.) |
| 講演論文情報詳細 | |
| 申込み研究会 | Technical Committee on Mathematical Systems Science and its applications |
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| 本文の言語 | ENG |
| タイトル（和） | |
| サブタイトル（和） | |
| タイトル（英） | A Colored Hybrid Petri Net Model for the Delta-Notch Dependent Boundary Formation in the Drosophila Large Intestine |
| サブタイトル（和） | |
| キーワード(1)（和/英） | colored hybrid Petri nets / colored hybrid Petri nets |
| キーワード(2)（和/英） | Delta-Notch signaling pathway / Delta-Notch signaling pathway |
| キーワード(3)（和/英） | boundary formation / boundary formation |
| キーワード(4)（和/英） | Drosophila large intestine / Drosophila large intestine |
| 第 1 著者 氏名（和/英） | Fei Liu / Fei Liu |
| 第 1 著者 所属（和/英） | Yamaguchi University(略称：山口大) Yamaguchi University(略称：Yamaguchi Univ.) |
| 第 2 著者 氏名（和/英） | Hiroshi Matsuno / Hiroshi Matsuno |
| 第 2 著者 所属（和/英） | Yamaguchi University(略称：山口大) Yamaguchi University(略称：Yamaguchi Univ.) |
| 第 3 著者 氏名（和/英） | Ryutaro Murakami / Ryutaro Murakami |
| 第 3 著者 所属（和/英） | Yamaguchi University(略称：山口大) Yamaguchi University(略称：Yamaguchi Univ.) |
| 発表年月日 | 2016-03-03 |
| 資料番号 | MSS2015-76 |
| 巻番号（vol） | vol.115 |
| 号番号（no） | MSS-480 |
| ページ範囲 | pp.47-52(MSS), |
| ページ数 | 6 |
| 発行日 | 2016-02-25 (MSS) |