| Presentation | 2016-03-03 A Colored Hybrid Petri Net Model for the Delta-Notch Dependent Boundary Formation in the Drosophila Large Intestine Fei Liu, Hiroshi Matsuno, Ryutaro Murakami, |
|---|---|
| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | The modeling of the boundary formation in the Drosophila large intestine is a typical mutiscale problem, and it is either time-consuming or hardly addressed by common modeling and simulation tools. As a powerful multiscale modeling and analysis tool for large-scale biological systems, colored hybrid Petri nets can be used to cope with such system. In this paper, we apply colored hybrid Petri nets to model the boundary formation in the large intestine of Drosophila embryo, and build a colored hybrid Petri net model for this biological phenomenon. We validate the model in the wild-type conditions and use the model to make predictions in different over-expression rates of Notch proteins, which well match the experimental observations in vivo. We have shown that colored Petri nets are very appropriate to model such multicellular systems, and our model is scalable and thus we can easily study the model behavior on different size of intestinal tissues. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | colored hybrid Petri nets / Delta-Notch signaling pathway / boundary formation / Drosophila large intestine |
| Paper # | MSS2015-76 |
| Date of Issue | 2016-02-25 (MSS) |
| Conference Information | |
| Committee | MSS |
|---|---|
| Conference Date | 2016/3/3(2days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | KAIKYO MESSE SHIMONOSEKI |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Chair | Satoshi Yamane(Kanazawa Univ.) |
| Vice Chair | Morikazu Nakamura(Univ. of Ryukyus) |
| Secretary | Morikazu Nakamura(Yamaguchi Univ.) |
| Assistant | Hideki Kinjo(Okinawa Univ.) |
| Paper Information | |
| Registration To | Technical Committee on Mathematical Systems Science and its applications |
|---|---|
| Language | ENG |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | A Colored Hybrid Petri Net Model for the Delta-Notch Dependent Boundary Formation in the Drosophila Large Intestine |
| Sub Title (in English) | |
| Keyword(1) | colored hybrid Petri nets |
| Keyword(2) | Delta-Notch signaling pathway |
| Keyword(3) | boundary formation |
| Keyword(4) | Drosophila large intestine |
| 1st Author's Name | Fei Liu |
| 1st Author's Affiliation | Yamaguchi University(Yamaguchi Univ.) |
| 2nd Author's Name | Hiroshi Matsuno |
| 2nd Author's Affiliation | Yamaguchi University(Yamaguchi Univ.) |
| 3rd Author's Name | Ryutaro Murakami |
| 3rd Author's Affiliation | Yamaguchi University(Yamaguchi Univ.) |
| Date | 2016-03-03 |
| Paper # | MSS2015-76 |
| Volume (vol) | vol.115 |
| Number (no) | MSS-480 |
| Page | pp.pp.47-52(MSS), |
| #Pages | 6 |
| Date of Issue | 2016-02-25 (MSS) |