| Presentation | 2016-01-19 Measurement of change in endogenous serotonin levels by PET dynamic analysis Yoko Ikoma, Hiroyuki Takuwa, Asuka Nishino, Chie Seki, Jun Maeda, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | The neurotransmitter, such as dopamine and serotonin, is related to depression, Parkinson disease, and other psychiatric or neurologic disorders. In the measurement of neuroreceptors using positron emission tomography (PET), the binding of administered radioligand to the receptors often competes with endogenous neurotransmitters. Therefore, an increase or decrease of the neurotransmitters in the synaptic cleft can be estimated from change in the binding of radioligand to the receptors. In this study, we targeted to the quantification of the change in the serotonin level, time-activity curves obtained by the PET dynamic scan were simulated using a compartment model including the administered radioligand and endogenous serotonin concentration. From these curves, we evaluated the analysis method for estimating the change in endogenous serotonin level, and validated the proposed method by small animal PET scans. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Positron Emission Tomography / Compartment Model / Serotonin Receptor / Binding Potential |
| Paper # | MI2015-85 |
| Date of Issue | 2016-01-12 (MI) |
| Conference Information | |
| Committee | MI |
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| Conference Date | 2016/1/19(2days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Bunka Tenbusu Kan |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | General topics in medical imaging |
| Chair | Yoshitaka Masutani(Hiroshima City Univ.) |
| Vice Chair | Yoshiki Kawata(Tokushima Univ.) / Yuichi Kimura(Kinki Univ.) |
| Secretary | Yoshiki Kawata(Aichi Inst. of Tech.) / Yuichi Kimura(Nagoya Inst. of Tech.) |
| Assistant | Ryo Haraguchi(NCVC) / Yasushi Hirano(Yamaguchi Univ.) |
| Paper Information | |
| Registration To | Technical Committee on Medical Imaging |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Measurement of change in endogenous serotonin levels by PET dynamic analysis |
| Sub Title (in English) | |
| Keyword(1) | Positron Emission Tomography |
| Keyword(2) | Compartment Model |
| Keyword(3) | Serotonin Receptor |
| Keyword(4) | Binding Potential |
| 1st Author's Name | Yoko Ikoma |
| 1st Author's Affiliation | National Institute of Radiological Sciences(NIRS) |
| 2nd Author's Name | Hiroyuki Takuwa |
| 2nd Author's Affiliation | National Institute of Radiological Sciences(NIRS) |
| 3rd Author's Name | Asuka Nishino |
| 3rd Author's Affiliation | National Institute of Radiological Sciences(NIRS) |
| 4th Author's Name | Chie Seki |
| 4th Author's Affiliation | National Institute of Radiological Sciences(NIRS) |
| 5th Author's Name | Jun Maeda |
| 5th Author's Affiliation | National Institute of Radiological Sciences(NIRS) |
| Date | 2016-01-19 |
| Paper # | MI2015-85 |
| Volume (vol) | vol.115 |
| Number (no) | MI-401 |
| Page | pp.pp.65-68(MI), |
| #Pages | 4 |
| Date of Issue | 2016-01-12 (MI) |