| Presentation | 2016-01-19 Algorithm for automated delineation of reference regions in PET amyloid imaging based on pattern recognition scheme and kinetics of administered tracer Takahiro Yamada, Yuichi Kimura, Takashi Nagaoka, Shima Okada, Chisa Hosokawa, Kazunari Ishii, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Deposit of amyloid beta (Aβ) caused Alzheimer disease (AD). Very early diagnosis of Aβ deposit is expected to an effective AD diagnosis, and it in realized by a periodical PET amyloid imaging. A quantitative Aβ imaging with PET requires a delineation of a reference region. The manual delineation suffers from low reliability. Accordingly, this study aims to propose the automated algorithm. That utilized a time history of an administered radiopharmaceutical in tissues. 86 clinical images including Aβ-deposit positive, equivocal, and negative were applied to the algorithm. Reference region were successfully delineated to 68 cases And, the others were successful after retrying and changing inputted images to the algorithm. Estimated binding potentials, a quantitative index on Aβ deposit, using the proposed algorithm were correspond with those with a conventional method. We conclude that the algorithm in useful for a reference region delineation. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | PET / kinetic analysis / Alzheimer’s Disease / Amyloid imaging |
| Paper # | MI2015-84 |
| Date of Issue | 2016-01-12 (MI) |
| Conference Information | |
| Committee | MI |
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| Conference Date | 2016/1/19(2days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Bunka Tenbusu Kan |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | General topics in medical imaging |
| Chair | Yoshitaka Masutani(Hiroshima City Univ.) |
| Vice Chair | Yoshiki Kawata(Tokushima Univ.) / Yuichi Kimura(Kinki Univ.) |
| Secretary | Yoshiki Kawata(Aichi Inst. of Tech.) / Yuichi Kimura(Nagoya Inst. of Tech.) |
| Assistant | Ryo Haraguchi(NCVC) / Yasushi Hirano(Yamaguchi Univ.) |
| Paper Information | |
| Registration To | Technical Committee on Medical Imaging |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Algorithm for automated delineation of reference regions in PET amyloid imaging based on pattern recognition scheme and kinetics of administered tracer |
| Sub Title (in English) | Performance evaluation using climical data |
| Keyword(1) | PET |
| Keyword(2) | kinetic analysis |
| Keyword(3) | Alzheimer’s Disease |
| Keyword(4) | Amyloid imaging |
| 1st Author's Name | Takahiro Yamada |
| 1st Author's Affiliation | Kindai University(Kindai) |
| 2nd Author's Name | Yuichi Kimura |
| 2nd Author's Affiliation | Kindai University(Kindai) |
| 3rd Author's Name | Takashi Nagaoka |
| 3rd Author's Affiliation | Kindai University(Kindai) |
| 4th Author's Name | Shima Okada |
| 4th Author's Affiliation | Kindai University(Kindai) |
| 5th Author's Name | Chisa Hosokawa |
| 5th Author's Affiliation | Kindai University(Kindai) |
| 6th Author's Name | Kazunari Ishii |
| 6th Author's Affiliation | Kindai University(Kindai) |
| Date | 2016-01-19 |
| Paper # | MI2015-84 |
| Volume (vol) | vol.115 |
| Number (no) | MI-401 |
| Page | pp.pp.59-63(MI), |
| #Pages | 5 |
| Date of Issue | 2016-01-12 (MI) |